橙皮素对醋酸铅诱导的大鼠氧化应激的抗氧化作用。
Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats.
机构信息
Department of Veterinary Medicine, College of Animal Science and Technology, Henan University of Science and Technology, No.70, Tianjin Road, 471003, Luoyang, PR China.
出版信息
Indian J Pharmacol. 2013 Jul-Aug;45(4):395-8. doi: 10.4103/0253-7613.115015.
OBJECTIVES
Oxidative stress with subsequent lipid peroxidation (LP) has been suggested as a mechanism for lead-induced toxicity. The current study was carried out to evaluate antioxidant activity of hesperetin against lead acetate-induced oxidative stress.
MATERIALS AND METHODS
The male rats were treated with hesperetin in combination with lead acetate (500 mg/L).
RESULTS
The results indicated that hesperetin alone did not induce any significant changes in the biochemistry of serum, liver, and kidney tissues. On the other hand, lead-induced oxidative stress as indicated by significant changes in serum biochemical parameters, including increased lipid peroxide and decreased reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) levels in liver and kidney tissues. Hesperetin succeeded in improving these biochemical parameters towards the normal values of control.
CONCLUSIONS
It suggests that hesperetin shows antioxidant activity and plays a protective role against lead-induced oxidative damage in liver and kidney of rats.
目的
氧化应激伴随着随后的脂质过氧化（LP）被认为是铅诱导毒性的一种机制。本研究旨在评估橙皮苷对醋酸铅诱导的氧化应激的抗氧化活性。
材料与方法
雄性大鼠用橙皮苷与醋酸铅（500mg/L）联合处理。
结果
结果表明，橙皮苷单独使用不会引起血清、肝脏和肾脏组织生化的显著变化。另一方面，铅诱导的氧化应激表现为血清生化参数的显著变化，包括肝和肾组织中脂质过氧化物增加，还原型谷胱甘肽（GSH）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）水平降低。橙皮苷成功地将这些生化参数改善至对照组的正常数值。
结论
这表明橙皮苷具有抗氧化活性，并在大鼠的肝和肾中发挥了对抗铅诱导的氧化损伤的保护作用。
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