Melebary Sahar J, Elnaggar Moustafa H R
Department of Biology, College of Science, University of Jeddah, Jeddah 21493, Saudi Arabia.
Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Saudi J Biol Sci. 2023 Jan;30(1):103507. doi: 10.1016/j.sjbs.2022.103507. Epub 2022 Nov 17.
This study aimed to assess the impact of () leaf extract against the poisoning of lead acetate; therefore, sixty mice were allocated into 4 groups with 15 in each, as G1) blank control, G2) supplied with 300 mg/kg body weight (BWT). extract, G3) supplied with 60 mg/kg BWT of lead acetate [Pb(CHO)], and G4) supplied with extract of + lead acetate. The liver enzymes were elevated post-treatment with Pb(CHO), which then lowered to almost the normal level when was supplied to mice previously treated with Pb(CHO). The values in (G3) decreased when compared with G1 (92.33 ± 12.99, 21.67 ± 2.91 and 98.00 ± 13.20 U/L, respectively. Also, the cholesterol and low-density lipoprotein levels were elevated post-supplementation with and Pb(CHO). Pb(CHO) improves the lipid profile, whereas pretreatment reduced cholesterol (CHOL), high density low cholesterol (HDL-c), and low-density low cholesterol (LDL-c) levels in animals fed Pb(CHO). Pb(CHO) elevates the total protein but lowers the total bilirubin and triglycerides post treatment and Pb(CHO) when contrasted with G1. The protective effect of was caused by the fact that it lowered triglycerides (TG) and total bilirubin (TBIL) and raised total protein (TP). After administration of Pb(CHO), the histological examination revealed alterations in the hepatocytes and kidneys of G3. Also, the liver and kidney cells in mice supplied with after Pb(CHO) poisoning recovered. In conclusion, Pb is toxic, and the usage of partially enhances the negative impacts induced by Pb(CHO).
本研究旨在评估（）叶提取物对醋酸铅中毒的影响；因此，将60只小鼠分为4组，每组15只，即G1）空白对照组，G2）给予300毫克/千克体重（BWT）的（）提取物，G3）给予60毫克/千克BWT的醋酸铅[Pb(CHO)]，G4）给予（）提取物 + 醋酸铅。用Pb(CHO)处理后肝酶升高，但在向先前用Pb(CHO)处理的小鼠提供（）后，肝酶降至几乎正常水平。与G1相比，G3中的值降低（分别为92.33±12.99、21.67±2.91和98.00±13.20 U/L）。此外，补充（）和Pb(CHO)后胆固醇和低密度脂蛋白水平升高。Pb(CHO)改善血脂谱，而预处理降低了喂食Pb(CHO)的动物的胆固醇（CHOL）、高密度低胆固醇（HDL-c）和低密度低胆固醇（LDL-c）水平。与G1相比，Pb(CHO)在处理和Pb(CHO)后可提高总蛋白，但降低总胆红素和甘油三酯。（）的保护作用是因为它降低了甘油三酯（TG）和总胆红素（TBIL）并提高了总蛋白（TP）。给予Pb(CHO)后，组织学检查显示G3的肝细胞和肾脏有改变。此外，Pb(CHO)中毒后给予（）的小鼠的肝和肾细胞恢复。总之，铅具有毒性，（）的使用部分增强了Pb(CHO)引起的负面影响。
