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越南北方2009 - 2012年流感病毒对奥司他韦的耐药性监测

Oseltamivir resistance among influenza viruses: surveillance in northern Viet Nam, 2009-2012.

作者信息

Hoang Vu Mai-Phuong, Nguyen Co Thach, Nguyen Le Khanh Hang, Nguyen Thi Kim Phuong, Le Quynh Mai

机构信息

National Influenza Center, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.

出版信息

Western Pac Surveill Response J. 2013 Jun 26;4(2):25-9. doi: 10.5365/WPSAR.2013.4.1.010. eCollection 2013 Apr-Jun.

DOI:10.5365/WPSAR.2013.4.1.010
PMID:24015368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3762967/
Abstract

INTRODUCTION

Antiviral resistance has been reported in seasonal influenza A viruses and avian influenza A(H5N1) viruses in Viet Nam, raising concerns about the efficacy of treatment.

METHODS

We analysed specimens from two sources during the period 2009-2012: influenza-positive samples from influenza-like illness patients at sentinel clinics in northern Viet Nam and isolates from patients with confirmed A(H5N1) infections. Pyrosequencing was used to detect mutations: H275Y [for A(H1N1) and A(H5N1)], E119V [for A(H3N2)] and I117V [for A(H5N1)]. A neuraminidase inhibition assay was used to determine the Inhibitory Concentration 50 (IC₅₀) values for all influenza A and B isolates.

RESULTS

There were 341 influenza A positive samples identified; influenza A(H1N1)pdm09 was identified most frequently (n = 215). In 2009, oseltamivir resistance was observed in 100% (19 of 19) of seasonal A(H1N1) isolates and 1.4% (3/215) of A(H1N1)pdm09 isolates. This H275Y mutation was not found in influenza subtypes A(H5N1) or A(H3N2) isolates.

DISCUSSION

In Viet Nam, seasonal and A(H5N1) influenza vaccines are not currently available; thus, effective treatment is required. The presence of oseltamivir-resistant viruses is therefore a concern. Active surveillance for oseltamivir resistance among influenza viruses circulating in Viet Nam should be continued.

摘要

引言

越南已报告季节性甲型流感病毒和甲型禽流感A(H5N1)病毒出现抗病毒耐药性，这引发了对治疗效果的担忧。

方法

我们分析了2009年至2012年期间来自两个来源的标本：越南北部哨点诊所流感样疾病患者的流感阳性样本以及确诊为A(H5N1)感染患者的分离株。焦磷酸测序用于检测突变：H275Y[针对A(H1N1)和A(H5N1)]、E119V[针对A(H3N2)]和I117V[针对A(H5N1)]。采用神经氨酸酶抑制试验测定所有甲型和乙型流感病毒分离株的半数抑制浓度(IC₅₀)值。

结果

共鉴定出341份甲型流感阳性样本；甲型H1N1)pdm09流感最为常见(n = 215)。2009年，在100%(19/19)的季节性A(H1N1)分离株和1.4%(3/215)的A(H1N1)pdm09分离株中观察到对奥司他韦耐药。在甲型H5N1或甲型H3N2流感病毒分离株中未发现这种H275Y突变。

讨论

在越南，目前没有季节性流感疫苗和A(H5N1)流感疫苗；因此，需要有效的治疗方法。因此，存在对奥司他韦耐药的病毒令人担忧。应继续对越南流行的流感病毒进行奥司他韦耐药性的主动监测。