Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan ; Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.
PLoS One. 2013 Sep 3;8(9):e71964. doi: 10.1371/journal.pone.0071964. eCollection 2013.
Recently, we reported that low reward dependence, and to a lesser extent, low cooperativeness in the Temperature and Character Inventory (TCI) may be risk factors for treatment-resistant depression. Here, we analyzed additional psychological traits in these patients.
We administered Costa and McCrae's five-factor model personality inventory, NEO Personality Inventory-Revised (NEO-PI-R), to antidepressant-treatment resistant depressed patients (n=35), remitted depressed patients (n=27), and healthy controls (n=66). We also evaluated the relationships between scores on NEO and TCI, using the same cohort of patients with treatment-resistant depression, as our previous study.
Patients with treatment-resistant depression showed high scores for neuroticism, low scores for extraversion, openness and conscientiousness, without changes in agreeableness, on the NEO. However, patients in remitted depression showed no significant scores on NEO. Patients with treatment-resistant depression and low openness on NEO showed positive relationships with reward dependence and cooperativeness on the TCI.
Many studies have reported that depressed patients show high neuroticism, low extraversion and low conscientiousness on the NEO. Our study highlights low openness on the NEO, as a risk mediator in treatment-resistant depression. This newly identified trait should be included as a risk factor in treatment-resistant depression.
最近，我们报告称，在温度和性格量表（TCI）中，低奖励依赖，在较小程度上，低合作性可能是治疗抵抗性抑郁症的危险因素。在这里，我们分析了这些患者的其他心理特征。
我们对抗抑郁治疗抵抗性抑郁症患者（n=35）、缓解抑郁症患者（n=27）和健康对照组（n=66）进行了 Costa 和 McCrae 的五因素模型人格量表、NEO 人格量表修订版（NEO-PI-R）。我们还使用我们之前的研究中相同的治疗抵抗性抑郁症患者队列，评估了 NEO 和 TCI 之间的分数关系。
治疗抵抗性抑郁症患者的 NEO 评分表现为神经质高、外向性低、开放性和尽责性低，亲社会性无明显变化。然而，缓解性抑郁症患者的 NEO 评分没有显著变化。在 NEO 中表现为开放性低的治疗抵抗性抑郁症患者与 TCI 中的奖励依赖和合作性呈正相关。
许多研究报告称，抑郁症患者在 NEO 上表现出高神经质、低外向性和低尽责性。我们的研究强调了 NEO 上的开放性低，作为治疗抵抗性抑郁症的中介风险因素。这一新发现的特征应被纳入治疗抵抗性抑郁症的风险因素。
