Fila L, Chladek J, Maly M, Musil J
Bratisl Lek Listy. 2013;114(9):503-7. doi: 10.4149/bll_2013_105.
To evaluate correlation of exhaled breath condensate (EBC) nitrite and nitrate concentrations with disease severity in cystic fibrosis (CF) patients.
Nitrites and nitrates are products of oxidative metabolism of nitric oxide. Impaired metabolism of nitric oxide plays a role in pathogenesis of CF.
EBC was collected from 46 stable CF patients and from 21 healthy controls. EBC concentrations of nitrites and nitrates were correlated with parameters of lung disease and nutritional status and with systemic inflammatory markers.
EBC nitrates concentrations in CF patients were lower than in healthy subjects (5.8 vs 14.3 μmol/l, p<0.001). They correlated positively with FEV1 (p=0.025) and serum albumin values (p=0.016) and negatively with chest radiograph Northern score (p=0.015) and serum C-reactive protein values (p=0.005). EBC nitrites concentrations in CF patients did not differ from those in healthy subjects and were not correlated to any studied parameter.
EBC nitrates concentrations correlate with disease severity in CF patients and are lower than in healthy subjects (Tab. 4, Fig. 1, Ref. 48).
评估囊性纤维化（CF）患者呼出气冷凝液（EBC）中亚硝酸盐和硝酸盐浓度与疾病严重程度的相关性。
亚硝酸盐和硝酸盐是一氧化氮氧化代谢的产物。一氧化氮代谢受损在CF发病机制中起作用。
收集46例病情稳定的CF患者和21例健康对照者的EBC。EBC中亚硝酸盐和硝酸盐浓度与肺部疾病参数、营养状况及全身炎症标志物相关。
CF患者的EBC硝酸盐浓度低于健康受试者（5.8 vs 14.3 μmol/l，p<0.001）。它们与第一秒用力呼气容积（FEV1）（p=0.025）和血清白蛋白值（p=0.016）呈正相关，与胸部X线片Northern评分（p=0.015）和血清C反应蛋白值（p=0.005）呈负相关。CF患者的EBC亚硝酸盐浓度与健康受试者无差异，且与任何研究参数均无相关性。
CF患者的EBC硝酸盐浓度与疾病严重程度相关，且低于健康受试者（表4，图1，参考文献48）。
