USC Bipar, Bartonella et Tiques, INRA, Anses, 23 Avenue du Général de Gaulle, 94 700 Maisons-Alfort, France.
Future Microbiol. 2013 Sep;8(9):1117-28. doi: 10.2217/fmb.13.77.
Among the 33 confirmed Bartonella species to date, more than half are hosted by rodent species, and at least five of them have been involved in human illness causing diverse symptoms including fever, myocarditis, endocarditis, lymphadenitis and hepatitis. In almost all countries, wild rodents are infected by extremely diverse Bartonella strains with a high prevalence. In the present paper, in light of new knowledge on rodent-adapted Bartonella species genomics, we bring together knowledge gained in recent years to have an overview of the impact of rodent-adapted Bartonella infection on humans and to determine how diversity of Bartonella helps to understand their mechanisms of adaptation to rodents and the consequences on human health.
迄今为止，在已确认的 33 种巴尔通体物种中，超过一半存在于啮齿动物宿主中，其中至少有 5 种与人类疾病有关，引起多种症状，包括发热、心肌炎、心内膜炎、淋巴结炎和肝炎。在几乎所有国家，野生啮齿动物都受到高度流行的高度多样化的巴尔通体菌株的感染。在本文中，根据关于适应啮齿动物的巴尔通体物种基因组学的新知识，我们汇集了近年来获得的知识，以概述适应啮齿动物的巴尔通体感染对人类的影响，并确定巴尔通体的多样性如何帮助我们理解它们适应啮齿动物的机制及其对人类健康的后果。
