Wilson M G, Michet C J, Ilstrup D M, Melton L J
Division of Rheumatology and Internal Medicine, Mayo Clinic, Rochester, MN 55905.
Mayo Clin Proc. 1990 Sep;65(9):1214-21. doi: 10.1016/s0025-6196(12)62745-1.
We identified all residents of Rochester, Minnesota, who sought medical assistance for the first time in 1985 because of symptomatic osteoarthritis of the hip or knee that was unrelated to a specific disease. Of these residents, 98 (59 women and 39 men) had 122 symptomatic joints (95 knees and 27 hips), for age- and sex-adjusted incidence rates of 205 new patients and 255 newly affected joints per 100,000 person-years. The incidence of osteoarthritis of the hip was greater in women than in men, whereas the sex ratio for occurrence of osteoarthritis of the knee approached unity. Rates at both sites increased steadily with aging in men but plateaued after the menopause in women; similar patterns were seen whether or not grade 1 disease was included. Projected nationally, these first population-based data indicate that as many as approximately half a million new symptomatic cases of idiopathic osteoarthritis of the knee and hip may arise annually in the white population of the United States. With increasing longevity, osteoarthritis may exact an even greater toll in the future.
我们确定了明尼苏达州罗切斯特市的所有居民，这些居民在1985年首次因与特定疾病无关的有症状的髋或膝骨关节炎寻求医疗救助。在这些居民中，98人（59名女性和39名男性）有122个有症状的关节（95个膝盖和27个髋关节），年龄和性别调整后的发病率为每10万人年有205名新患者和255个新受影响的关节。髋骨关节炎的发病率女性高于男性，而膝骨关节炎的发病性别比接近1。两个部位的发病率在男性中均随年龄稳步上升，但在女性绝经后趋于平稳；无论是否包括1级疾病，都观察到类似的模式。据全国推算，这些基于人群的首批数据表明，在美国白人人群中，每年可能出现多达约50万例新的有症状的特发性髋和膝骨关节炎病例。随着寿命的延长，骨关节炎在未来可能造成更大的损失。
