Gajendra Smeeta, Gupta Richa, Gupta Ritu, Kumar Lalit
Laboratory Oncology Unit, DR BR A IRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
BMJ Case Rep. 2013 Sep 10;2013:bcr2013200639. doi: 10.1136/bcr-2013-200639.
Coexistence of scleroderma with multiple myeloma (MM) is an unusual finding with unclear significance. Only 13 cases of MM with scleroderma have been reported until now. We report a case of a 24-year-old man with 8-year history of progressive thickening of skin all over the body. Histopathology of skin lesion was consistent with scleroderma. Bone marrow biopsy showed interstitial and focal increase in plasma cells and increased bone marrow fibrosis. Skeletal survey showed osteopenia, but no osteolytic lesion or fracture. The patient was diagnosed as scleroderma with coexistence of immunoglobulin A, κMM. The patient recovered with improvement of skin lesions after 9 months of therapy with thalidomide and dexamethasone.
硬皮病与多发性骨髓瘤（MM）并存是一种罕见的情况，其意义尚不清楚。迄今为止，仅报道了13例合并硬皮病的MM病例。我们报告一例24岁男性，有8年全身皮肤进行性增厚病史。皮肤病变的组织病理学与硬皮病相符。骨髓活检显示浆细胞间质和局灶性增多以及骨髓纤维化增加。骨骼检查显示骨质减少，但无溶骨性病变或骨折。该患者被诊断为硬皮病合并免疫球蛋白A、κ型MM。患者在接受沙利度胺和地塞米松治疗9个月后皮肤病变改善，病情康复。
