Department of Ophthalmology, Jinling Hospital, Nanjing University, Nanjing, China.
PLoS One. 2013 Sep 4;8(9):e74723. doi: 10.1371/journal.pone.0074723. eCollection 2013.
Sleep duration has been shown to play an important role in the development of cancer. However, the results have been inconsistent. A meta-analysis with prospective cohort studies was performed to clarify the association between short or long sleep duration and cancer risk.
PubMed and Embase databases were searched for eligible publications. Pooled relative risk (RR) with 95% confidence interval (CI) was calculated using random- or fixed- model.
A total of 10 prospective studies (8392 incident cases and 555678 participants) were included in the meta-analysis. Neither short nor long sleep duration was statistically associated with increased risk of cancer (short sleep duration: RR=1.05, 95%CI=0.90-1.24, p=0.523; long sleep duration: RR=0.92, 95%CI=0.76-1.12, p=0.415). In the subgroup by cancer type, long sleep duration was positively associated with colorectal cancer (RR=1.29, 95%CI=1.09-1.52, p=0.003).
The present meta-analysis suggested that neither short nor long sleep duration was significantly associated with risk of cancer, although long sleep duration increased risk of with colorectal cancer. Large-scale well-design prospective studies are required to be conducted to further investigate the observed association.
睡眠时长在癌症的发展中起着重要作用。然而，结果并不一致。进行了一项荟萃分析，纳入了前瞻性队列研究，以明确短或长睡眠时长与癌症风险之间的关联。
检索 PubMed 和 Embase 数据库以获取符合条件的文献。使用随机或固定模型计算汇总相对风险（RR）及其 95%置信区间（CI）。
荟萃分析共纳入 10 项前瞻性研究（8392 例发病病例和 555678 名参与者）。短或长睡眠时长均与癌症风险增加无关（短睡眠时长：RR=1.05，95%CI=0.90-1.24，p=0.523；长睡眠时长：RR=0.92，95%CI=0.76-1.12，p=0.415）。按癌症类型亚组分析，长睡眠时长与结直肠癌呈正相关（RR=1.29，95%CI=1.09-1.52，p=0.003）。
本荟萃分析表明，短或长睡眠时长与癌症风险均无显著相关性，尽管长睡眠时长增加了结直肠癌的风险。需要开展大规模、精心设计的前瞻性研究，以进一步探究观察到的关联。
