Heldgaard P E
Ugeskr Laeger. 1990 Aug 20;152(34):2427-8.
ACE-inhibitors have long been considered to be connected with only a few side-effects. Their use in clinical practice has shown that a considerable number of patients develop a dry, non-productive cough, resistant to treatment. The cause is hitherto unknown, but ACE-inhibition has been proved to alter the cough reflex. Non-smokers seem to cough more often than smokers, and females more often than males. Registration of side-effects in 28 patients treated for arterial hypertension in general practice in the years 1985-1988 is presented.
长期以来，人们一直认为血管紧张素转换酶抑制剂（ACE-inhibitors）只会引发少数副作用。它们在临床实践中的应用表明，相当多的患者会出现一种顽固性干咳，常规治疗无效。其病因至今不明，但已证实ACE抑制作用会改变咳嗽反射。非吸烟者似乎比吸烟者更容易咳嗽，女性比男性更易出现这种情况。本文介绍了1985 - 1988年在普通医疗中对28例动脉高血压患者进行副作用登记的情况。
