Department of Mental Health, Consorci Sanitari de Terrassa, Terrassa (Barcelona), Spain.
Schizophr Res. 2013 Nov;150(2-3):563-9. doi: 10.1016/j.schres.2013.08.025. Epub 2013 Sep 11.
Quality of life (QoL) is an important outcome in the treatment of schizophrenia. Cognitive deficits have an impact on functional outcomes. Cognitive remediation therapy is emerging as a psychological intervention that targets cognitive impairment, but the effect of computer-assisted cognitive remediation on neuropsychology and social functioning and wellbeing remains unclear. The aim of the current study is to investigate the neurocognitive outcomes of computer-assisted cognitive remediation (CACR) therapy in a sample of schizophrenia patients, and to measure the quality of life and self-esteem as secondary outcomes.
Sixty-seven people with schizophrenia were randomly assigned to computer-assisted cognitive remediation or an active control condition. The main outcomes were neuropsychological measures and secondary outcomes (self-esteem and quality of life). Measurements were recorded at baseline and post-treatment.
The CACR therapy group improved in speed of processing, working memory and reasoning and problem-solving cognitive domains. QoL and self-esteem measures also showed significant improvements over time in this group.
Computer-assisted cognitive remediation therapy for people with schizophrenia achieved improvements in neuropsychological performance and in QoL and self-esteem measurements.
生活质量（QoL）是精神分裂症治疗的一个重要结果。认知缺陷对功能结果有影响。认知矫正治疗作为一种针对认知障碍的心理干预措施正在出现，但计算机辅助认知矫正对神经心理学、社会功能和幸福感的影响仍不清楚。本研究的目的是调查计算机辅助认知矫正（CACR）治疗对精神分裂症患者的神经认知结果，并将生活质量和自尊作为次要结果进行测量。
67 名精神分裂症患者被随机分配到计算机辅助认知矫正或主动对照组。主要结果是神经心理学测量和次要结果（自尊和生活质量）。在基线和治疗后进行测量。
CACR 治疗组在处理速度、工作记忆、推理和解决问题的认知领域有改善。在这个组中，生活质量和自尊测量也随着时间的推移有显著改善。
计算机辅助认知矫正治疗精神分裂症患者在神经心理学表现以及生活质量和自尊测量方面取得了改善。
