Colletti Giacomo, Allevi Fabiana, Valassina Davide, Bertossi Dario, Biglioli Federico
From the Department of Maxillofacial Surgery, San Paolo Hospital, University of Milan, Milan, Italy.
J Craniofac Surg. 2013;24(5):1734-8. doi: 10.1097/SCS.0b013e3182a2355a.
Cocaine snorting may cause significant local ischemic necrosis and the destruction of nasal and midfacial bones and soft tissues, leading to the development of a syndrome called cocaine-induced midline destructive lesion. A review of the English-language literature reveals only a few articles describing the treatment of hard and/or soft palatal perforation related to cocaine inhalation. Described here are 4 patients with a history of cocaine abuse showing palatal lesions.
From 2010 to 2013, a total of 4 patients affected by cocaine-related midline destructive lesions were referred to our department. They all presented signs of a cocaine-induced midline destructive lesion. They showed wide midfacial destruction involving the nasal septum as well as the hard and soft palates causing an ample oronasal communication.
In 3 patients, oronasal communication has been treated successfully using a personal technique based on a partially de-epithelialized forearm free flap. The fourth patient had been treated only with local debridement because, when she came to our attention, her abusive habits were still unsolved.
Different surgical options have been reported such as local, regional, and free flaps for hard and soft palate reconstruction. However, because of an unpredictable vascularization of the palatal tissues and owing to the scarceness of the local soft tissues, local flaps are at high risk for partial and complete failure. The transfer of free vascularized tissue, however, seems to be the most reliable and logical solution for medium- to large-sized fistulas. Among the various free flaps, we choose the radial forearm type because of the pedicle length and the flap thickness.
吸食可卡因可能导致严重的局部缺血性坏死以及鼻和中面部骨骼与软组织的破坏,进而引发一种名为可卡因诱发的中线破坏性病变的综合征。对英文文献的回顾显示,仅有少数文章描述了与可卡因吸入相关的硬腭和/或软腭穿孔的治疗。本文介绍了4例有可卡因滥用史且出现腭部病变的患者。
2010年至2013年期间,共有4例受可卡因相关中线破坏性病变影响的患者被转诊至我科。他们均表现出可卡因诱发的中线破坏性病变的体征。他们呈现出广泛的中面部破坏,累及鼻中隔以及硬腭和软腭,导致口鼻腔广泛相通。
3例患者采用基于部分去上皮化的前臂游离皮瓣的个人技术成功治疗了口鼻腔相通问题。第4例患者仅接受了局部清创治疗,因为在我们关注到她时,她的滥用习惯仍未戒除。
已报道了不同的手术选择,如用于硬腭和软腭重建的局部、区域和游离皮瓣。然而,由于腭部组织血管化情况不可预测且局部软组织稀缺,局部皮瓣发生部分或完全失败的风险很高。然而,游离带血管组织的转移似乎是中大型瘘管最可靠且合理的解决方案。在各种游离皮瓣中,我们选择桡侧前臂皮瓣类型是因为其蒂部长度和皮瓣厚度。