Kliniken-Valens, Department of Sports Therapy, Rehabilitationsklinik Valens, 7317, Valens, Switzerland,
J Neurol. 2013 Dec;260(12):2993-3001. doi: 10.1007/s00415-013-7091-z. Epub 2013 Sep 14.
The influences of exercise on cytokine response, health-related quality of life (HR-QoL), and fatigue are important aspects of MS rehabilitation. Physical exercises performed within these programs are often practiced in water, but the effects of immersion have not been investigated. To investigate the influences of short-term immune responses and cardiorespiratory fitness on HR-QoL and fatigue during 3 weeks endurance training conducted on a cycle-ergometer or an aquatic-bike. Randomized controlled clinical trial in 60 MS patients. HR-QoL, fatigue, cardiorespiratory fitness, and short-term immune changes (serum concentrations in response to cardiopulmonary exercise test) of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), interleukin-6, and the soluble receptor of IL-6 (sIL-6R) were determined at the beginning and end of 3 weeks of training intervention. Subjects performed daily 30 min training at 60 % of their VO2peak. SF-36 total (p = 0.031), physical (p = 0.004), and mental health (p = 0.057) scores show time effects within both groups. Between-group effects were shown for FSMC total (p = 0.040) and motor function score (p = 0.041). MFIS physical fatigue showed time effects (p = 0.008) for both groups. Linear regression models showed relationships between short-term immune responses and cardiorespiratory fitness with HR-QoL and fatigue after the intervention. This study indicates beneficial effects of endurance training independent of the training setting. Short-term immune adaptations and cardiorespiratory fitness have the potential to influence HR-QoL and fatigue in persons with MS. The specific immune responses of immersion to exercise need further clarification.
运动对细胞因子反应、健康相关生活质量（HR-QoL）和疲劳的影响是 MS 康复的重要方面。这些方案中进行的体育锻炼通常在水中进行，但浸润的影响尚未得到研究。本研究旨在探讨短期免疫反应和心肺功能适应性对在功率自行车或水上自行车进行 3 周耐力训练期间 HR-QoL 和疲劳的影响。这是一项 60 例 MS 患者参与的随机对照临床试验。在 3 周的训练干预开始和结束时，测定 HR-QoL、疲劳、心肺功能适应性以及脑源性神经营养因子（BDNF）、神经生长因子（NGF）、白细胞介素-6（IL-6）和 IL-6 可溶性受体（sIL-6R）的短期免疫变化（心肺运动试验后血清浓度）。受试者每天进行 30 分钟、60%峰值摄氧量的训练。SF-36 总分（p = 0.031）、生理（p = 0.004）和心理健康（p = 0.057）评分在两组内均显示出时间效应。组间效应显示在 FSMC 总分（p = 0.040）和运动功能评分（p = 0.041）上。MFIS 身体疲劳在两组中均显示出时间效应（p = 0.008）。线性回归模型显示，干预后短期免疫反应和心肺功能适应性与 HR-QoL 和疲劳之间存在关系。本研究表明，无论训练环境如何，耐力训练都有有益的影响。短期免疫适应和心肺功能适应性有可能影响 MS 患者的 HR-QoL 和疲劳。对运动的浸润的特定免疫反应需要进一步阐明。
