Caldeira Thaís Duquia Moraes, Gonçalves Carla Vitola, Oliveira Gisele Rodrigues de, Fonseca Tânia Vieira da, Gonçalves Regina, Amaral Clair Teixeira do, Hora Vanusa Pousada da, Martinez Ana Maria Barral de
Rev Inst Med Trop Sao Paulo. 2013 Sep-Oct;55(5):315-21. doi: 10.1590/S0036-46652013000500004.
The herpes simplex virus type 2 (HVS-2) is the most prevalent infection worldwide. It is a cofactor in the acquisition of human immunodeficiency virus (HIV) and the persistence of human papillomavirus (HPV). This study evaluated the prevalence of HSV-2, using the polymerase chain reaction (PCR), and associated factors in patients treated at the Federal University of Rio Grande (FURG) and Basic Health Units (BHU) in Rio Grande, Brazil. The observed prevalence of HSV-2 was 15.6%. Among the 302 women studied, 158 had received assistance in BHU and 144 were treated at FURG. The prevalence of HSV-2 in these groups was 10.8% and 20.8%, respectively, RR 1.9 and p = 0.012. Knowledge about the Pap smear, and the presence of lesions showed no association with HSV-2 infection. Multivariate analysis showed that the variable that most influenced the risk of HSV-2 infection was the presence of HIV infection, with a relative risk of 1.9 and p = 0.04.
Genital ulcers are an important entry point for HIV, and condom use is an important strategy to reduce transmission of HIV and HSV-2.
单纯疱疹病毒2型（HSV - 2）是全球最普遍的感染病毒。它是人类免疫缺陷病毒（HIV）感染及人乳头瘤病毒（HPV）持续感染的一个辅助因素。本研究采用聚合酶链反应（PCR）评估了巴西里奥格兰德联邦大学（FURG）和里奥格兰德基层卫生单位（BHU）接受治疗的患者中HSV - 2的流行情况及相关因素。观察到的HSV - 2流行率为15.6%。在302名接受研究的女性中，158名在BHU接受治疗，144名在FURG接受治疗。这些组中HSV - 2的流行率分别为10.8%和20.8%，相对危险度为1.9，p = 0.012。关于巴氏涂片的知识以及病变的存在与HSV - 2感染无关联。多变量分析表明，对HSV - 2感染风险影响最大的变量是HIV感染的存在，相对危险度为1.9，p = 0.04。
生殖器溃疡是HIV的一个重要感染途径，使用避孕套是减少HIV和HSV - 2传播的一项重要策略
