Departamento de Metodologia da Pesquisa, Instituto de Pós-Graduação Médica Carlos Chagas, Rio de Janeiro, RJ, Brasil.
Rev Saude Publica. 2010 Aug;44(4):726-34. doi: 10.1590/s0034-89102010000400017.
To estimate the seroprevalence of HSV-1 and HSV-2 antibodies in Brazil and to analyze factors associated.
Cross-sectional study including subjects aged 1-40 years from the general population in four different geographical areas in Brazil between 1996 and 1997. All subjects were stratified by age and gender and 1,090 of them were included in the final analysis. Blood samples were tested for HSV-1 and HSV-2 antibodies by type-specific (gG1 and gG2) ELISA. Frequencies and proportions were described and compared among groups using two-sided Fisher's exact test. A logistic regression analysis was performed to assess the influence of the variables age, gender, geographical area, socioeconomic condition, past history of STD, seropositivity for anti-HSV-1 or anti-HSV-2 and interactions of any of these factors on the seroprevalence of HSV-1 and/or HSV-2.
The age-adjusted seroprevalences of HSV-1 and HSV-2 antibodies were 67.2% and 11.3%, respectively, without sex differences and being higher in the North region. Seroprevalences increased with age and, for HSV-2 infection, the higher increase was observed among adolescents and young adults. Subjects who tested positive for HSV-1 were more likely to also test positive for HSV-2 (15.7%) compared to HSV-1 negative subjects (4.7%). In the multivariate analysis past history of STD significantly (OR=3.2) increased the likelihood of HSV-2 infection whereas socioeconomic condition did not affect the results.
HSV-1 and HSV-2 seroprevalences vary with age and among Brazilian regions. Past history of STD is a major risk factor for HSV-2 infection.
估计巴西人群中单纯疱疹病毒 1 型（HSV-1）和单纯疱疹病毒 2 型（HSV-2）抗体的血清流行率，并分析相关因素。
这是一项 1996 至 1997 年期间在巴西四个不同地理区域的一般人群中进行的横断面研究，纳入了 1 至 40 岁的研究对象。所有研究对象按年龄和性别分层，其中 1090 人纳入最终分析。采用型特异性（gG1 和 gG2）酶联免疫吸附试验（ELISA）检测 HSV-1 和 HSV-2 抗体。使用双侧 Fisher 确切检验描述和比较组间的频率和比例。采用 logistic 回归分析评估变量（年龄、性别、地理区域、社会经济状况、性传播疾病史、HSV-1 或 HSV-2 抗体血清阳性率以及这些因素之间的相互作用）对 HSV-1 和/或 HSV-2 血清流行率的影响。
年龄校正后的 HSV-1 和 HSV-2 抗体血清流行率分别为 67.2%和 11.3%，无性别差异，且北部地区较高。血清流行率随年龄增长而增加，对于 HSV-2 感染，青少年和青年人群中观察到的增加幅度更大。与 HSV-1 阴性者（4.7%）相比，HSV-1 阳性者更有可能也感染 HSV-2（15.7%）。多变量分析显示，性传播疾病史显著（比值比=3.2）增加了 HSV-2 感染的可能性，而社会经济状况未影响结果。
HSV-1 和 HSV-2 的血清流行率随年龄和巴西地区而异。性传播疾病史是 HSV-2 感染的主要危险因素。
