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阿瑞米他霉素 A：通过对土壤宏基因组的序列导向筛选来改善具有临床相关性的天然产物家族。

Arimetamycin A: improving clinically relevant families of natural products through sequence-guided screening of soil metagenomes.

机构信息

Laboratory of Genetically Encoded Small Molecules, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065 (USA) http://lab.rockefeller.edu/brady/

出版信息

Angew Chem Int Ed Engl. 2013 Oct 11;52(42):11063-7. doi: 10.1002/anie.201305109. Epub 2013 Sep 3.

DOI:10.1002/anie.201305109
PMID:24038656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3878715/
Abstract

Sequence-tag-guided screening of soil environmental DNA libraries can be used to guide the discovery of new compounds with improved properties. In heterologous expression experiments the eDNA-derived arm cluster encodes arimetamycin A, an anthracycline that is more potent than clinically used natural anthracyclines and retains activity against multidrug-resistant (MDR) cancer cells.

摘要

序列标签引导的土壤环境 DNA 文库筛选可用于指导新化合物的发现，改善其性质。在异源表达实验中，eDNA 衍生的 arm 簇编码阿霉素 A，一种蒽环类抗生素，比临床使用的天然蒽环类抗生素更有效，并保留对多药耐药 (MDR) 癌细胞的活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d94/3878715/7f887812ce8f/nihms534433f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d94/3878715/6eea258e7a78/nihms534433f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d94/3878715/be0cde18f372/nihms534433f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d94/3878715/eec7cb55dc76/nihms534433f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d94/3878715/7f887812ce8f/nihms534433f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d94/3878715/6eea258e7a78/nihms534433f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d94/3878715/be0cde18f372/nihms534433f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d94/3878715/eec7cb55dc76/nihms534433f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d94/3878715/7f887812ce8f/nihms534433f4.jpg

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2
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3
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