Larsen C P, Morris P J, Austyn J M
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, United Kingdom.
J Exp Med. 1990 Jan 1;171(1):307-14. doi: 10.1084/jem.171.1.307.
It has been a long-standing dogma that host sensitization against fully-vascularized organ allografts occurs peripherally within the graft itself. In this report we show that donor-derived MHC class II-positive (Ia+) DL migrate rapidly out of mouse cardiac allografts into the recipients' spleens where they home to the peripheral white pulp and associate predominantly with CD4+ T lymphocytes. This provides a novel route for central sensitization against fully vascularized allografts, and most likely represents a pathway by which immune responses are generated against antigens on blood-borne DL emigrating from peripheral tissues.
长期以来的教条认为，宿主对完全血管化的器官同种异体移植物的致敏在外周移植物自身内发生。在本报告中，我们表明供体来源的MHC II类阳性（Ia+）树突状细胞（DL）迅速从小鼠心脏同种异体移植物中迁移到受体脾脏，在那里它们归巢到外周白髓并主要与CD4+T淋巴细胞相关联。这为针对完全血管化同种异体移植物的中枢致敏提供了一条新途径，并且很可能代表了一种针对从外周组织迁出的血源性DL上的抗原产生免疫反应的途径。
