派古瑞安和前卡瑞波米德，两种海洋蓝细菌 Moorea producens 来源的脂肽。
Parguerene and precarriebowmide, two classes of lipopeptides from the marine cyanobacterium Moorea producens.
机构信息
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego , La Jolla, California 92093, United States.
出版信息
J Nat Prod. 2013 Sep 27;76(9):1810-4. doi: 10.1021/np400347f. Epub 2013 Sep 17.
Abstract
Two new marine cyanobacterial natural products, parguerene (1) and precarriebowmide (2), were isolated from a collection of Moorea producens obtained from La Parguera, Puerto Rico. The planar structures of both were deduced by 2D NMR spectroscopy and mass spectrometry. Parguerene is a modified acyl amide with some structural similarity to the bacterial metabolite stipiamide (3), whereas precarriebowmide is a lipopeptide and represents a minor modification compared to two other known metabolites, carriebowmide (4) and carriebowmide sulfone (5). The identification of 2 led to an investigation into whether carriebowmide and carriebowmide sulfone were true secondary metabolites or isolation artifacts.
摘要
从波多黎各拉帕格鲁拉采集的莫雷亚产色菌中分离到两种新型海洋蓝细菌天然产物
parguerene（1）和 precarriebowmide（2）。通过二维 NMR 光谱和质谱推断出两者的平面结构。parguerene 是一种经过修饰的酰基酰胺，与细菌代谢产物 stipiamide（3）具有一定的结构相似性，而 precarriebowmide 是一种脂肽，与另外两种已知代谢物 carriebowmide（4）和 carriebowmide sulfone（5）相比，只是略有修饰。鉴定出 2 后，我们研究了 carriebowmide 和 carriebowmide sulfone 是否真的是次级代谢产物还是分离过程中的人为产物。
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