National Institute for Health and Welfare (THL), Helsinki, Finland.
J Virol. 2013 Dec;87(23):13076-80. doi: 10.1128/JVI.01174-13. Epub 2013 Sep 18.
Highly divergent vaccine-derived polioviruses (VDPVs) have been isolated from sewage in Tallinn, Estonia, since 2002. Sequence analysis of VDPVs of serotypes 2 and 3 showed that they shared common noncapsid region recombination sites, indicating origination from a single trivalent oral polio vaccine dose, estimated to have been given between 1986 and 1998. The sewage isolates closely resemble VDPVs chronically excreted by persons with common variable immunodeficiency, but no chronic excretors have yet been identified in Estonia.
自 2002 年以来,在爱沙尼亚塔林的污水中已经分离到了高度变异的疫苗衍生脊髓灰质炎病毒(VDPV)。对血清型 2 和 3 的 VDPV 的序列分析表明,它们具有共同的非衣壳区重组位点,表明起源于单次使用三价口服脊髓灰质炎疫苗,估计接种时间在 1986 年至 1998 年之间。污水分离株与常见可变免疫缺陷患者慢性排泄的 VDPV 非常相似,但在爱沙尼亚尚未发现慢性排泄者。