Orthopaedic Research and Biotechnology, Research Building, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145,
Eur Cell Mater. 2013 Sep 20;26:120-32. doi: 10.22203/ecm.v026a09.
Bone tissue engineering has emerged as one of the leading fields in tissue engineering and regenerative medicine. The success of bone tissue engineering relies on understanding the interplay between progenitor cells, regulatory signals, and the biomaterials/scaffolds used to deliver them--otherwise known as the tissue engineering triad. This review will discuss the roles of these fundamental components with a specific focus on the interaction between cell behaviour and scaffold structural properties. In terms of scaffold architecture, recent work has shown that pore size can affect both cell attachment and cellular invasion. Moreover, different materials can exert different biomechanical forces, which can profoundly affect cellular differentiation and migration in a cell type specific manner. Understanding these interactions will be critical for enhancing the progress of bone tissue engineering towards clinical applications.
骨组织工程已成为组织工程和再生医学的主要领域之一。骨组织工程的成功依赖于对祖细胞、调节信号以及用于传递它们的生物材料/支架之间相互作用的理解——这也被称为组织工程三联体。本综述将讨论这些基本组成部分的作用，特别关注细胞行为和支架结构特性之间的相互作用。就支架结构而言，最近的研究表明，孔径大小会影响细胞黏附和细胞浸润。此外，不同的材料可以产生不同的生物力学力，这些力可以以细胞类型特异性的方式深刻影响细胞分化和迁移。理解这些相互作用对于促进骨组织工程向临床应用的进展至关重要。
