Zhao Peng, Stephens Jacqueline M
Department of Biological Sciences; Louisiana State University; Baton Rouge, LA USA ; Adipocyte Biology Lab; Pennington Biomedical Research Center; Baton Rouge, LA USA.
JAKSTAT. 2013 Apr 1;2(2):e23092. doi: 10.4161/jkst.23092.
Adipocytes play important roles in lipid storage, energy homeostasis and whole body insulin sensitivity. Studies in the last two decades have identified the hormones and cytokines that activate specific STATs in adipocytes in vitro and in vivo. Five of the seven STAT family members are expressed in adipocyte (STATs 1, 3, 5A, 5B and 6). Many transcription factors, including STATs, have been shown to play an important role in adipose tissue development and function. This review will summarize the importance of adipocytes, indicate the cytokines and hormones that utilize the JAK-STAT signaling pathway in fat cells and focus on the identification of STAT target genes in mature adipocytes. To date, specific target genes have been identified for STATs, 1, 5A and 5B, but not for STATs 3 and 6.
脂肪细胞在脂质储存、能量稳态及全身胰岛素敏感性方面发挥着重要作用。过去二十年的研究已确定了在体外和体内激活脂肪细胞中特定信号转导和转录激活因子（STATs）的激素和细胞因子。七个STAT家族成员中有五个在脂肪细胞中表达（STATs 1、3、5A、5B和6）。许多转录因子，包括STATs，已被证明在脂肪组织发育和功能中起重要作用。本综述将总结脂肪细胞的重要性，指出在脂肪细胞中利用JAK-STAT信号通路的细胞因子和激素，并着重于鉴定成熟脂肪细胞中的STAT靶基因。迄今为止，已确定了STATs 1、5A和5B的特定靶基因，但尚未确定STATs 3和6的靶基因。
