Xu Dong, Yin Chunyan, Wang Sisi, Xiao Yanfeng
Department of Pediatrics; Second Affiliated Hospital of Medical School of Xi'an; Jiaotong University; Xi'an, Shaanxi PR China.
JAKSTAT. 2013 Oct 1;2(4):e27203. doi: 10.4161/jkst.27203. Epub 2013 Dec 6.
JAK-STAT signaling pathway plays an important role in the cells' development and homeostasis. Over the past decades, the studies have identified the role of the JAK-STAT pathway in cell proliferation and apoptosis. Here, we want to discuss that whether and how the JAK-STAT pathway affects the lipid metabolism of adipose tissue. A host of cytokines and hormones can regulate lipid metabolism through activating the JAK-STAT signaling pathway. Activated STATs can regulate lipid metabolism directly by influencing the expression of enzymes. We have summarized the relevant research and articles of JAK-STAT during the recent years. Within this review, we will introduce you the recent research and highlight the unresolved problems in understanding how JAK-STAT signaling pathway contribute to the lipid metabolism in mature adipocytes and preadipocytes. Dysregulation of the JAK-STAT pathway would lead to a multiple metabolism disorders and medicines for this signaling pathway maybe become a new idea for diseases such as metabolic syndrome, especially in children.
JAK-STAT信号通路在细胞发育和内环境稳态中发挥着重要作用。在过去几十年里，研究已经明确了JAK-STAT通路在细胞增殖和凋亡中的作用。在此，我们想要探讨JAK-STAT通路是否以及如何影响脂肪组织的脂质代谢。许多细胞因子和激素可通过激活JAK-STAT信号通路来调节脂质代谢。激活的信号转导和转录激活因子（STATs）可通过影响酶的表达直接调节脂质代谢。我们总结了近年来关于JAK-STAT的相关研究和文章。在本综述中，我们将向您介绍最新研究，并突出在理解JAK-STAT信号通路如何促进成熟脂肪细胞和前脂肪细胞脂质代谢方面尚未解决的问题。JAK-STAT通路失调会导致多种代谢紊乱，针对该信号通路的药物可能成为治疗代谢综合征等疾病的新思路，尤其是在儿童中。
