Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, People's Republic of China; Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Haikou 571101, People's Republic of China.
Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Science & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, People's Republic of China.
Fitoterapia. 2013 Dec;91:224-230. doi: 10.1016/j.fitote.2013.09.007. Epub 2013 Sep 21.
Five new diterpenoids named excocarinols A-E (1-5) including three pimaranes, one cleistanthane, and one nor-beyerane, together with nine known compounds, were isolated from the EtOAc extract of the Chinese ethnodrug Gua-jing-ban (Excoecaria acerifolia Didr.). Their structures were elucidated by the analysis of spectroscopic data including 1D, 2D NMR and HR-MS. The anti-HIV-1 bioassay on the diterpenoids showed that excocarinol A (1) exhibited moderate anti-HIV-1 activity with EC50 5.58 μM and SI (Selection Index) over 112.71.
从中国民族药鬼箭羽（Excoecaria acerifolia Didr.）的乙酸乙酯提取物中分离得到了五个新的二萜类化合物，分别命名为 excocarinols A-E（1-5），包括三个 pimaranes，一个 cleistanthane 和一个 nor-beyerane，以及九个已知化合物。通过分析包括 1D、2D NMR 和 HR-MS 在内的光谱数据，阐明了它们的结构。对二萜类化合物的抗 HIV-1 活性测试表明，化合物 excocarinol A（1）表现出中等的抗 HIV-1 活性，EC50 为 5.58 μM，选择指数超过 112.71。
