由两亲小分子形成的光控离子通道通过顺反式光异构化来调节离子传导。
Light-controlled ion channels formed by amphiphilic small molecules regulate ion conduction via cis-trans photoisomerization.
机构信息
Shanghai Key Laboratory of Functional Materials Chemistry, Institute of Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, P. R. China.
出版信息
Chem Commun (Camb). 2013 Nov 11;49(87):10311-3. doi: 10.1039/c3cc45618h.
PMID:24064555
Abstract
Light-regulated ion channel-transport across lipid bilayers was realized using structurally simple azobenzene-based amphiphilic small molecules. UV or visible irradiation triggers molecular photoisomerization, which induces structural and membrane affinity changes in self-assembled channels, thus resulting in light-regulated ion transmembrane transport.
摘要
利用结构简单的基于偶氮苯的两亲性小分子实现了光调控的离子通道在脂质双层中的传输。紫外光或可见光照射会引发分子光致异构化，这会导致自组装通道的结构和膜亲和力发生变化，从而实现光控离子跨膜传输。
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