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Pharmacokinetics of insulin aspart in pump-treated subjects with type 1 diabetes: reproducibility and effect of age, weight, and duration of diabetes.门冬胰岛素在1型糖尿病胰岛素泵治疗患者中的药代动力学：重现性及年龄、体重和糖尿病病程的影响
Diabetes Care. 2013 Oct;36(10):e173-4. doi: 10.2337/dc13-0485.
2
A Comparison of Pharmacokinetic and Pharmacodynamic Properties Between Faster-Acting Insulin Aspart and Insulin Aspart in Elderly Subjects with Type 1 Diabetes Mellitus.门冬胰岛素与赖脯胰岛素在老年1型糖尿病患者中的药代动力学和药效学特性比较。
Drugs Aging. 2017 Jan;34(1):29-38. doi: 10.1007/s40266-016-0418-6.
3
Pharmacokinetics of diluted (U20) insulin aspart compared with standard (U100) in children aged 3-6 years with type 1 diabetes during closed-loop insulin delivery: a randomised clinical trial.在1型糖尿病3至6岁儿童闭环胰岛素输注期间，稀释（U20）门冬胰岛素与标准（U100）门冬胰岛素的药代动力学比较：一项随机临床试验。
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Faster-acting insulin aspart provides faster onset and greater early exposure vs insulin aspart in children and adolescents with type 1 diabetes mellitus.门冬胰岛素相较于门冬胰岛素类似物，起效更快，可为 1 型糖尿病患儿和青少年提供更快的早期暴露。
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Fiasp--another insulin aspart formulation for diabetes.
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Investigation of Pump Compatibility of Fast-Acting Insulin Aspart in Subjects With Type 1 Diabetes.1型糖尿病患者中门冬胰岛素快速起效的泵兼容性研究。
J Diabetes Sci Technol. 2018 Jan;12(1):145-151. doi: 10.1177/1932296817730375. Epub 2017 Sep 18.
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Clinical Pharmacology of Fast-Acting Insulin Aspart Versus Insulin Aspart Measured as Free or Total Insulin Aspart and the Relation to Anti-Insulin Aspart Antibody Levels in Subjects with Type 1 Diabetes Mellitus.1 型糖尿病患者速效门冬胰岛素与门冬胰岛素游离或总浓度的临床药代动力学及其与抗门冬胰岛素抗体水平的关系。
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Faster Insulin Aspart: A New Bolus Option for Diabetes Mellitus.门冬胰岛素：糖尿病患者的新型餐时胰岛素选择。
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Improved Postprandial Glycemic Control with Faster-Acting Insulin Aspart in Patients with Type 1 Diabetes Using Continuous Subcutaneous Insulin Infusion.在1型糖尿病患者中，使用持续皮下胰岛素输注时，使用速效门冬胰岛素可改善餐后血糖控制。
Diabetes Technol Ther. 2017 Jan;19(1):25-33. doi: 10.1089/dia.2016.0350. Epub 2017 Jan 5.
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A Pooled Analysis of Clinical Pharmacology Trials Investigating the Pharmacokinetic and Pharmacodynamic Characteristics of Fast-Acting Insulin Aspart in Adults with Type 1 Diabetes.一项关于速效胰岛素门冬氨酸在1型糖尿病成人患者中药代动力学和药效学特征的临床药理学试验的汇总分析。
Clin Pharmacokinet. 2017 May;56(5):551-559. doi: 10.1007/s40262-017-0514-8.

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The 'Designer' Artificial Pancreas: How Does Current Technology Mimic Pancreatic Physiology?“定制”人工胰腺：当前技术如何模拟胰腺生理功能？
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Automated insulin delivery during the first 6 months postpartum (AiDAPT): a prespecified extension study.产后前6个月的自动胰岛素给药（AiDAPT）：一项预先设定的扩展研究。
Lancet Diabetes Endocrinol. 2025 Mar;13(3):210-220. doi: 10.1016/S2213-8587(24)00340-1. Epub 2025 Jan 27.
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Neural Networks With Gated Recurrent Units Reduce Glucose Forecasting Error Due to Changes in Sensor Location.带有门控循环单元的神经网络可减少因传感器位置变化导致的血糖预测误差。
J Diabetes Sci Technol. 2024 Jan;18(1):124-134. doi: 10.1177/19322968221100839. Epub 2022 Jun 4.
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Examining Sensor Agreement in Neural Network Blood Glucose Prediction.检查神经网络血糖预测中的传感器一致性。
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Glucose Prediction under Variable-Length Time-Stamped Daily Events: A Seasonal Stochastic Local Modeling Framework.可变时长时间戳每日事件下的葡萄糖预测：一种季节性随机局部建模框架
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Long-Term Glucose Forecasting Using a Physiological Model and Deconvolution of the Continuous Glucose Monitoring Signal.长期血糖预测使用生理模型和连续血糖监测信号的反卷积。
Sensors (Basel). 2019 Oct 8;19(19):4338. doi: 10.3390/s19194338.
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Unannounced Meals in the Artificial Pancreas: Detection Using Continuous Glucose Monitoring.未通知的餐食在人工胰腺中的检测：使用连续血糖监测。
Sensors (Basel). 2018 Mar 16;18(3):884. doi: 10.3390/s18030884.
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A coordinated control strategy for insulin and glucagon delivery in type 1 diabetes.1型糖尿病中胰岛素和胰高血糖素递送的协调控制策略。
Comput Methods Biomech Biomed Engin. 2017 Oct;20(13):1474-1482. doi: 10.1080/10255842.2017.1378352. Epub 2017 Sep 20.
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Enhancing automatic closed-loop glucose control in type 1 diabetes with an adaptive meal bolus calculator - in silico evaluation under intra-day variability.使用自适应餐时大剂量计算器增强1型糖尿病的自动闭环血糖控制——日内变异性下的计算机模拟评估
Comput Methods Programs Biomed. 2017 Jul;146:125-131. doi: 10.1016/j.cmpb.2017.05.010. Epub 2017 Jun 1.
10
Faster insulin action is associated with improved glycaemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy in adults with type 1 diabetes.闭环胰岛素输注和传感器增强型泵治疗期间，胰岛素作用更快与 1 型糖尿病成人患者血糖控制改善相关。
Diabetes Obes Metab. 2017 Oct;19(10):1485-1489. doi: 10.1111/dom.12956. Epub 2017 Jun 23.

本文引用的文献

1
Persistence of prolonged C-peptide production in type 1 diabetes as measured with an ultrasensitive C-peptide assay.用超敏 C 肽分析法测定 1 型糖尿病患者 C 肽延长分泌的持续时间。
Diabetes Care. 2012 Mar;35(3):465-70. doi: 10.2337/dc11-1236.
2
Dose-dependent delay of the hypoglycemic effect of short-acting insulin analogs in obese subjects with type 2 diabetes: a pharmacokinetic and pharmacodynamic study.肥胖 2 型糖尿病患者中速效胰岛素类似物的降糖作用呈剂量依赖性延迟：一项药代动力学和药效学研究。
Diabetes Care. 2010 Dec;33(12):2502-7. doi: 10.2337/dc10-1126. Epub 2010 Sep 14.
3
Direct comparison of insulin lispro and aspart shows small differences in plasma insulin profiles after subcutaneous injection in type 1 diabetes.赖脯胰岛素和门冬胰岛素的直接比较显示，在1型糖尿病患者皮下注射后，血浆胰岛素曲线存在细微差异。
Diabetes Care. 2001 Jun;24(6):1120-1. doi: 10.2337/diacare.24.6.1120.
4
Variability of the metabolic effect of soluble insulin and the rapid-acting insulin analog insulin aspart.可溶性胰岛素和速效胰岛素类似物门冬胰岛素代谢效应的变异性
Diabetes Care. 1998 Nov;21(11):1910-4. doi: 10.2337/diacare.21.11.1910.
5
Relationship between absorption of radiolabeled soluble insulin, subcutaneous blood flow, and anthropometry.放射性标记可溶性胰岛素的吸收、皮下血流与人体测量学之间的关系。
Diabetes Care. 1992 Nov;15(11):1484-93. doi: 10.2337/diacare.15.11.1484.

Pharmacokinetics of insulin aspart in pump-treated subjects with type 1 diabetes: reproducibility and effect of age, weight, and duration of diabetes.

作者信息

Haidar Ahmad, Elleri Daniela, Kumareswaran Kavita, Leelarathna Lalantha, Allen Janet M, Caldwell Karen, Murphy Helen R, Wilinska Malgorzata E, Acerini Carlo L, Evans Mark L, Dunger David B, Nodale Marianna, Hovorka Roman

机构信息

Corresponding author: Roman Hovorka,

出版信息

Diabetes Care. 2013 Oct;36(10):e173-4. doi: 10.2337/dc13-0485.

DOI:10.2337/dc13-0485
PMID:24065849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3781562/
Abstract
摘要