Shibata Motoko, Usui Yoshihiko, Ueda Shunichiro, Matsumura Hajime, Nagao Toshitaka, Goto Hiroshi
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
Clin Ophthalmol. 2013;7:1825-7. doi: 10.2147/OPTH.S44639. Epub 2013 Sep 16.
Although conjunctival squamous cell carcinoma is known to develop as a result of chronic irritation from wearing an ocular prosthesis, orbital sebaceous gland carcinoma arising in an anophthalmic pocket is extremely rare. We report a 68-year-old female who developed a sebaceous gland carcinoma 65 years after her right eye was enucleated (at the age of three years) due to congenital glaucoma. The patient had noticed increasing discharge and swelling of her right eyelid. Incisional biopsies of an underlying orbital mass revealed poorly differentiated sebaceous gland carcinoma. The sebaceous gland carcinoma in this case could have been caused by chronic irritation as a result of long-standing use of a poorly fitted ocular prosthesis. The current case of a malignant tumor occurring 65 years after enucleation emphasizes the importance of long-term clinical surveillance to monitor for tumor formation. Careful examination of the anophthalmic socket should be part of the physical examination.
尽管已知结膜鳞状细胞癌是因佩戴眼假体引起的慢性刺激而发生，但发生于无眼球凹陷处的眼眶皮脂腺癌极为罕见。我们报告一例68岁女性，其右眼因先天性青光眼在3岁时被摘除，65年后发生了皮脂腺癌。患者注意到右眼眼睑分泌物增多且肿胀。对眼眶肿物进行切开活检，结果显示为低分化皮脂腺癌。本例中的皮脂腺癌可能是长期使用佩戴不合适的眼假体导致慢性刺激所致。本例眼球摘除65年后发生恶性肿瘤的情况强调了长期临床监测以监测肿瘤形成的重要性。对无眼球眼眶进行仔细检查应成为体格检查的一部分。
