Bacterial Pathogenesis Laboratory, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Anaerobe. 2013 Dec;24:94-7. doi: 10.1016/j.anaerobe.2013.09.008. Epub 2013 Sep 25.
Clostridium difficile is the leading cause of antibiotic-associated diarrhea in healthcare facilities worldwide. C. difficile infections are difficult to treat because of the high rate of disease recurrence after antibiotic therapy, leaving few treatment options for patients. C. difficile is also difficult to contain within a healthcare setting due to a highly-transmissible, resistant spore form that challenges standard infection control measures. The recent development of murine infection models to study the interactions between C. difficile, the host and the microbiota are providing novel insight into the mechanisms of pathogenesis and transmission that should guide the development of therapies and intervention measures.
艰难梭菌是全球医疗保健机构中抗生素相关性腹泻的主要原因。由于抗生素治疗后疾病复发率高，艰难梭菌感染难以治疗，患者的治疗选择有限。由于具有高度传染性和耐药性的孢子形式，艰难梭菌在医疗环境中也难以控制，这给标准的感染控制措施带来了挑战。最近开发的用于研究艰难梭菌、宿主和微生物组之间相互作用的小鼠感染模型，为发病机制和传播机制提供了新的见解，这些见解应指导治疗和干预措施的开发。
