• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

我们孵化出成瘾之卵了吗:奖赏缺乏综合征解决方案系统™

Have We Hatched the Addiction Egg: Reward Deficiency Syndrome Solution System™.

作者信息

Downs Bw, Oscar-Berman M, Waite Rl, Madigan Ma, Giordano J, Beley T, Jones S, Simpatico T, Hauser M, Borsten J, Marcelo F, Braverman Er, Lohmann R, Dushaj K, Helman M, Barh D, Schoenthaler St, Han D, Blum K

机构信息

Department of Nutrigenomics, LifeGen, Inc., Austin, Texas, USA.

出版信息

J Genet Syndr Gene Ther. 2013 Jun 3;4(136):14318. doi: 10.4172/2157-7412.1000136.

DOI:10.4172/2157-7412.1000136
PMID:24077767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3783340/
Abstract

This article co-authored by a number of scientists, ASAM physicians, clinicians, treatment center owners, geneticists, neurobiologists, psychologists, social workers, criminologists, nurses, nutritionist, and students, is dedicated to all the people who have lost loved ones in substance-abuse and "reward deficiency syndrome" related tragedies. Why are we failing at reducing the incidence of 'Bad Behaviors'? Are we aiming at the wrong treatment targets for behavioral disorders? We are proposing a paradigm shift and calling it providing evidence for its adoption.

摘要

本文由多位科学家、美国成瘾医学协会医生、临床医生、治疗中心所有者、遗传学家、神经生物学家、心理学家、社会工作者、犯罪学家、护士、营养师和学生共同撰写,献给所有在与药物滥用和“奖赏缺乏综合征”相关的悲剧中失去亲人的人们。为什么我们在降低“不良行为”发生率方面未能取得成效?我们针对行为障碍的治疗目标是否有误?我们正在提出一种范式转变,并呼吁采用它并提供相关证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2b0/3783340/5a13aaa9e9c8/nihms494481f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2b0/3783340/5a13aaa9e9c8/nihms494481f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2b0/3783340/5a13aaa9e9c8/nihms494481f1.jpg

相似文献

1
Have We Hatched the Addiction Egg: Reward Deficiency Syndrome Solution System™.我们孵化出成瘾之卵了吗:奖赏缺乏综合征解决方案系统™
J Genet Syndr Gene Ther. 2013 Jun 3;4(136):14318. doi: 10.4172/2157-7412.1000136.
2
A Review of DNA Risk Alleles to Determine Epigenetic Repair of mRNA Expression to Prove Therapeutic Effectiveness in Reward Deficiency Syndrome (RDS): Embracing "Precision Behavioral Management".关于DNA风险等位基因的综述,以确定mRNA表达的表观遗传修复,从而证明在奖赏缺乏综合征(RDS)中的治疗效果:采用“精准行为管理”
Psychol Res Behav Manag. 2021 Dec 17;14:2115-2134. doi: 10.2147/PRBM.S292958. eCollection 2021.
3
Hypothesizing That Neuropharmacological and Neuroimaging Studies of Glutaminergic-Dopaminergic Optimization Complex (KB220Z) Are Associated With "Dopamine Homeostasis" in Reward Deficiency Syndrome (RDS).假设谷氨酰胺能 - 多巴胺能优化复合物(KB220Z)的神经药理学和神经影像学研究与奖赏缺乏综合征(RDS)中的“多巴胺稳态”相关。
Subst Use Misuse. 2017 Mar 21;52(4):535-547. doi: 10.1080/10826084.2016.1244551. Epub 2016 Dec 29.
4
Hatching the behavioral addiction egg: Reward Deficiency Solution System (RDSS)™ as a function of dopaminergic neurogenetics and brain functional connectivity linking all addictions under a common rubric.孵化行为成瘾的蛋:奖励缺陷解决方案系统(RDSS)作为多巴胺能神经遗传学和将所有成瘾联系在一起的大脑功能连接的功能,在一个共同的范畴下。
J Behav Addict. 2014 Sep;3(3):149-56. doi: 10.1556/JBA.3.2014.019. Epub 2014 Aug 26.
5
Common Neurogenetic Diagnosis and Meso-Limbic Manipulation of Hypodopaminergic Function in Reward Deficiency Syndrome (RDS): Changing the Recovery Landscape.奖赏缺乏综合征(RDS)中常见神经遗传学诊断及多巴胺能功能减退的中脑边缘系统调控:改变康复前景
Curr Neuropharmacol. 2017;15(1):184-194. doi: 10.2174/1570159x13666160512150918.
6
Coupling Neurogenetics (GARS™) and a Nutrigenomic Based Dopaminergic Agonist to Treat Reward Deficiency Syndrome (RDS): Targeting Polymorphic Reward Genes for Carbohydrate Addiction Algorithms.结合神经遗传学(GARS™)和基于营养基因组学的多巴胺能激动剂治疗奖赏缺乏综合征(RDS):针对碳水化合物成瘾算法的多态性奖赏基因
J Reward Defic Syndr. 2015;1(2):75-80. doi: 10.17756/jrds.2015-012. Epub 2015 Jun 24.
7
Neurogenetics and Nutrigenomics of Neuro-Nutrient Therapy for Reward Deficiency Syndrome (RDS): Clinical Ramifications as a Function of Molecular Neurobiological Mechanisms.奖赏缺乏综合征(RDS)神经营养疗法的神经遗传学与营养基因组学:作为分子神经生物学机制函数的临床影响
J Addict Res Ther. 2012 Nov 27;3(5):139. doi: 10.4172/2155-6105.1000139.
8
Genetic Addiction Risk Score (GARS): molecular neurogenetic evidence for predisposition to Reward Deficiency Syndrome (RDS).遗传成瘾风险评分(GARS):奖赏缺乏综合征(RDS)易感性的分子神经遗传学证据。
Mol Neurobiol. 2014 Dec;50(3):765-96. doi: 10.1007/s12035-014-8726-5. Epub 2014 May 31.
9
The Future is Now for Precision Genomic Addiction Medicine as a Frontline Modality for Inducing "Dopamine Homeostasis" in Reward Deficiency Syndrome (RDS).精准基因组成瘾医学作为在奖赏缺乏综合征(RDS)中诱导“多巴胺稳态”的一线治疗手段,未来已来。
Curr Pharm Biotechnol. 2023 Apr 27. doi: 10.2174/1389201024666230427111117.
10
The Benefits of Genetic Addiction Risk Score (GARS) Testing in Substance Use Disorder (SUD).基因成瘾风险评分(GARS)检测在物质使用障碍(SUD)中的益处。
Int J Genom Data Min. 2018;2018(1). doi: 10.29014/IJGD-115.000015. Epub 2018 Jan 15.

引用本文的文献

1
Invited Expert Opinion- Bioinformatic and Limitation Directives to Help Adopt Genetic Addiction Risk Screening and Identify Preaddictive Reward Dysregulation: Required Analytic Evidence to Induce Dopamine Homeostatsis.特邀专家意见——生物信息学与局限性指令,以助力采用遗传成瘾风险筛查并识别预测性奖赏失调:诱导多巴胺稳态所需的分析证据
Med Res Arch. 2023 Sep 14;11(8). doi: 10.18103/mra.v11i8.4211.
2
Reward Deficiency Syndrome Solution System (RDSSS) A Genetically Driven Putative Inducer of "Dopamine Homeostasis" as a Futuristic Alternative to Enhance Rehabilitation Instead of Incarceration.奖励缺乏综合征解决方案系统(RDSSS):一种由基因驱动的“多巴胺稳态”推定诱导剂,作为增强康复而非监禁的未来替代方案。
Asian J Complement Altern Med. 2023;11(1):11-14. doi: 10.53043/2347-3894.acam11003. Epub 2023 Jan 11.
3

本文引用的文献

1
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.五种主要精神疾病具有共同影响的风险基因座的鉴定:全基因组分析。
Lancet. 2013 Apr 20;381(9875):1371-1379. doi: 10.1016/S0140-6736(12)62129-1. Epub 2013 Feb 28.
2
The addictive brain: all roads lead to dopamine.上瘾的大脑:所有的路都通向多巴胺。
J Psychoactive Drugs. 2012 Apr-Jun;44(2):134-43. doi: 10.1080/02791072.2012.685407.
3
The process addictions and the new ASAM definition of addiction.成瘾过程和新的 ASAM 成瘾定义。
A Review of DNA Risk Alleles to Determine Epigenetic Repair of mRNA Expression to Prove Therapeutic Effectiveness in Reward Deficiency Syndrome (RDS): Embracing "Precision Behavioral Management".关于DNA风险等位基因的综述,以确定mRNA表达的表观遗传修复,从而证明在奖赏缺乏综合征(RDS)中的治疗效果:采用“精准行为管理”
Psychol Res Behav Manag. 2021 Dec 17;14:2115-2134. doi: 10.2147/PRBM.S292958. eCollection 2021.
4
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.促多巴胺调节剂(KB220PAM)与纳曲酮联合预防阿片类物质使用障碍复发的证据分析
EC Psychol Psychiatr. 2018 Aug;7(8):564-579. Epub 2018 Jul 30.
5
"Dopamine homeostasis" requires balanced polypharmacy: Issue with destructive, powerful dopamine agents to combat America's drug epidemic.“多巴胺稳态”需要平衡的联合用药:使用具有破坏性的强效多巴胺药物来对抗美国的毒品泛滥问题。
J Syst Integr Neurosci. 2017 Nov;3(6). doi: 10.15761/JSIN.1000183. Epub 2017 Nov 17.
6
Neurophysiological Measures and Alcohol Use Disorder (AUD): Hypothesizing Links between Clinical Severity Index and Molecular Neurobiological Patterns.神经生理学测量与酒精使用障碍(AUD):推测临床严重程度指数与分子神经生物学模式之间的联系。
J Addict Res Ther. 2016 Apr;5(2). doi: 10.4172/2155-6105.1000181. Epub 2016 Apr 26.
7
THE BENEFITS OF CUSTOMIZED DNA DIRECTED NUTRITION TO BALANCE THE BRAIN REWARD CIRCUITRY AND REDUCE ADDICTIVE BEHAVIORS.定制化DNA导向营养对平衡大脑奖赏回路及减少成瘾行为的益处。
Precis Med (Bangalore). 2016;1(1):18-33. Epub 2016 Aug 1.
8
Stimulants for the Control of Hedonic Appetite.用于控制享乐性食欲的兴奋剂。
Front Pharmacol. 2016 Apr 25;7:105. doi: 10.3389/fphar.2016.00105. eCollection 2016.
9
Low Impulsive Action, but not Impulsive Choice, Predicts Greater Conditioned Reinforcer Salience and Augmented Nucleus Accumbens Dopamine Release.低冲动行为而非冲动选择预示着更强的条件性强化物显著性和伏隔核多巴胺释放增强。
Neuropsychopharmacology. 2016 Jul;41(8):2091-100. doi: 10.1038/npp.2016.9. Epub 2016 Jan 19.
10
Neuroscience of Internet Pornography Addiction: A Review and Update.网络色情成瘾的神经科学:综述与更新
Behav Sci (Basel). 2015 Sep 18;5(3):388-433. doi: 10.3390/bs5030388.
J Psychoactive Drugs. 2012 Jan-Mar;44(1):1-4. doi: 10.1080/02791072.2012.662105.
4
Neurogenetics and clinical evidence for the putative activation of the brain reward circuitry by a neuroadaptagen: proposing an addiction candidate gene panel map.神经遗传学和临床证据表明,神经适应原可能激活大脑奖励回路:提出成瘾候选基因图谱。
J Psychoactive Drugs. 2011 Apr-Jun;43(2):108-27. doi: 10.1080/02791072.2011.587393.
5
Overcoming qEEG abnormalities and reward gene deficits during protracted abstinence in male psychostimulant and polydrug abusers utilizing putative dopamine D₂ agonist therapy: part 2.在男性精神兴奋剂和多药滥用者长期戒断期间克服 qEEG 异常和奖励基因缺陷:第 2 部分。
Postgrad Med. 2010 Nov;122(6):214-26. doi: 10.3810/pgm.2010.11.2237.
6
Weight gain is associated with reduced striatal response to palatable food.体重增加与对美味食物的纹状体反应减少有关。
J Neurosci. 2010 Sep 29;30(39):13105-9. doi: 10.1523/JNEUROSCI.2105-10.2010.
7
Nutrigenomic targeting of carbohydrate craving behavior: can we manage obesity and aberrant craving behaviors with neurochemical pathway manipulation by Immunological Compatible Substances (nutrients) using a Genetic Positioning System (GPS) Map?针对碳水化合物渴望行为的营养基因组学靶向:我们能否通过使用遗传定位系统(GPS)地图,利用免疫兼容物质(营养素)对神经化学途径进行操纵来管理肥胖和异常渴望行为?
Med Hypotheses. 2009 Sep;73(3):427-34. doi: 10.1016/j.mehy.2009.02.037. Epub 2009 May 17.
8
Striatal dopamine D2 receptor binding and dopamine release during cue-elicited craving in recently abstinent opiate-dependent males.近期戒毒的阿片类药物依赖男性在提示引发的渴望期间纹状体多巴胺D2受体结合及多巴胺释放情况。
Eur Neuropsychopharmacol. 2008 Apr;18(4):262-70. doi: 10.1016/j.euroneuro.2007.11.002.
9
Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation.药物依赖,一种慢性疾病:对治疗、保险及疗效评估的影响
JAMA. 2000 Oct 4;284(13):1689-95. doi: 10.1001/jama.284.13.1689.
10
Increased prevalence of the Taq I A1 allele of the dopamine receptor gene (DRD2) in obesity with comorbid substance use disorder: a preliminary report.多巴胺受体基因(DRD2)的Taq I A1等位基因在伴有物质使用障碍的肥胖症中的患病率增加:一项初步报告。
Pharmacogenetics. 1996 Aug;6(4):297-305. doi: 10.1097/00008571-199608000-00003.