J Neural Transm (Vienna). 2014 Feb;121(2):139-45. doi: 10.1007/s00702-013-1093-y.
Visual symptoms are common among the nonmotor symptoms in Parkinson’s disease. The aims of this study were to assess the diagnostic accuracy and relationship of retinal morphologic and functional changes with motor and non-motor symptoms disturbances in Parkinson’s disease. Thirty patients with Parkinson’s disease, with a median Hoehn-Yahr stage of 2 (1-4), were compared to 30 age- and gender-matched controls. Retinal thinning and function were measured using optical coherence tomography (OCT), visual evoked potentials (VEP), and pattern electroretinography. Motor impairment and motor laterality were measured using the Short Parkinson’s Evaluation Scale/Scales for Outcomes in Parkinson’s disease, and non-motor symptoms severity using the nonmotor symptoms questionnaire. Only pattern electroretinography, P50 and N95 amplitudes, were lower in patients with Parkinson’s disease, compared to controls (p = 0.01, respectively). Age, disease duration, levodopa dose, motor, and non-motor impairment were not significantly associated with retinal thinning and functional changes. The patients vs. controls area under the curve of OCT, VEP, and pattern electroretinography receiver-operating-characteristic curves were<0.50. In conclusion, morphologic and functional retina changes are not significantly correlated with motor and non-motor symptoms impairment severity, and do not discriminate between Parkinson’s disease and controls.
视觉症状在帕金森病的非运动症状中很常见。本研究旨在评估视网膜形态和功能变化与帕金森病运动和非运动症状障碍的诊断准确性和关系。将 30 名帕金森病患者（中位数 Hoehn-Yahr 分期为 2（1-4））与 30 名年龄和性别匹配的对照进行比较。使用光学相干断层扫描（OCT）、视觉诱发电位（VEP）和图形视网膜电图测量视网膜变薄和功能。使用帕金森病简易评价量表/帕金森病结局评分量表测量运动障碍和运动偏侧性，使用非运动症状问卷测量非运动症状严重程度。与对照组相比，帕金森病患者的图形视网膜电图、P50 和 N95 振幅较低（p = 0.01）。年龄、疾病持续时间、左旋多巴剂量、运动和非运动损伤与视网膜变薄和功能变化无显著相关性。与对照组相比，患者 vs. 对照组的 OCT、VEP 和图形视网膜电图受试者工作特征曲线下面积均<0.50。总之，形态和功能视网膜变化与运动和非运动症状损伤严重程度无显著相关性，也不能区分帕金森病和对照组。
