Department of Cardiology, University of Debrecen, Debrecen, Hungary.
Mayo Clin Proc. 2013 Oct;88(10):1167-73. doi: 10.1016/j.mayocp.2013.06.019.
We describe a patient with the coincidence of 2 ion channel disorders with autosomal dominant inheritance: Brugada syndrome, a potentially fatal cardiac condition, and cryptogenic focal epilepsy, likely due to a neurologic channelopathy. Although Brugada syndrome was discovered incidentally, most of the clinical features of epilepsy in this patient shared the risk factor characteristics of sudden unexplained death in epilepsy syndrome. This case provides additional information on the potential interaction between ion channel abnormalities in the heart and in the brain. Furthermore, it may suggest that patients with epilepsy at increased risk for sudden unexplained death in epilepsy syndrome should undergo a careful cardiac evaluation.
Brugada 综合征，一种潜在致命的心脏疾病，和隐源性局灶性癫痫，可能是由于神经通道病引起的。尽管 Brugada 综合征是偶然发现的，但该患者癫痫的大多数临床特征都具有癫痫猝死综合征的突发不明原因死亡的危险因素特征。该病例提供了关于心脏和大脑中离子通道异常之间潜在相互作用的更多信息。此外，它可能表明癫痫猝死综合征风险增加的癫痫患者应进行仔细的心脏评估。
