46 Paleon Polemiston St., 166 74, Attica, Greece.
QJM. 2014 Jan;107(1):25-32. doi: 10.1093/qjmed/hct194. Epub 2013 Sep 30.
The aim of this study was to evaluate the effect of high intensity, interval exercise on quality of life (QoL) and depression status, in chronic heart failure (CHF) patients.
A randomized controlled trial (phase III). Of the 100 consecutive CHF patients (NYHA classes II-IV, ejection fraction ≤ 50%) that were randomly allocated to exercise intervention (n = 50, high-intensity intermittent endurance training 30 s at 100% of max workload, 30 s at rest, for 45 min/day-by-12 weeks) or no exercise advice (n = 50), 72 (exercise group, n = 33, 63 ± 9 years, 88% men, 70% ischemic CHF and control group, n = 39, 56 ± 11 years, 82% men, 70% ischemic CHF) completed the study. QoL was assessed using the validated and translated Minnesota Living with Heart Failure questionnaire. Depressive symptomatology was evaluated using the validated and translated Zung Depression Rating Scale (ZDRS). Maximal oxygen uptake (VO(2max)) and carbon dioxide production (VCO(2max)) were also measured breath-by-breath.
Data analysis demonstrated that in the intervention group MLHFQ score was reduced by 66% (P = 0.003); 6-min-walk distance increased by 13% (P < 0.05), VO(2max) level increased by 31% (P = 0.001), VCO(2max) level increased by 28% (P = 0.001) and peak power output increased by 25% (P = 0.001), as compared with the control group.
High intensity, systematic aerobic training, could be strongly encouraged in CHF patients, since it improves QoL, by favorably modifying their fitness level.
本研究旨在评估高强度间歇运动对慢性心力衰竭（CHF）患者生活质量（QoL）和抑郁状态的影响。
这是一项随机对照试验（III 期）。100 例连续的 CHF 患者（NYHA 心功能分级 II-IV 级，射血分数≤50%）被随机分为运动干预组（n=50，高强度间歇耐力训练，100%最大工作负荷 30 秒，休息 30 秒，每天 45 分钟，共 12 周）或不进行运动建议组（n=50）。72 例（运动组，n=33，63±9 岁，82%为男性，70%为缺血性 CHF；对照组，n=39，56±11 岁，82%为男性，70%为缺血性 CHF）完成了研究。使用经过验证和翻译的明尼苏达州心力衰竭生活质量问卷评估 QoL。使用经过验证和翻译的zung 抑郁评定量表（ZDRS）评估抑郁症状。也通过呼吸测量最大摄氧量（VO₂max）和二氧化碳产生量（VCO₂max）。
数据分析表明，在干预组中，MLHFQ 评分降低了 66%（P=0.003）；6 分钟步行距离增加了 13%（P<0.05），VO₂max 水平增加了 31%（P=0.001），VCO₂max 水平增加了 28%（P=0.001），峰值功率输出增加了 25%（P=0.001），与对照组相比。
高强度、系统的有氧运动可以强烈鼓励 CHF 患者进行，因为它通过有利地改变他们的健康水平来提高生活质量。
