Chrysohoou Christina, Angelis Athanasios, Tsitsinakis George, Spetsioti Stavroula, Nasis Ioannis, Tsiachris Dimitris, Rapakoulias Panagiotis, Pitsavos Christos, Koulouris Nikolaos G, Vogiatzis Ioannis, Dimitris Tousoulis
First Cardiology Clinic, Hippokration Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
First Cardiology Clinic, Hippokration Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Int J Cardiol. 2015 Jan 20;179:269-74. doi: 10.1016/j.ijcard.2014.11.067. Epub 2014 Nov 6.
The aim of this work was to evaluate the effect of high-intensity interval exercise (i.e., 30s at 100% of max workload, followed by 30s at rest, 45 min 3 days/week working-out schedule for 12 weeks) on left ventricular function and aortic elastic properties among chronic heart failure (CHF) patients.
This study is a phase III clinical trial. Of the 100 consecutive CHF patients (NYHA classes II-IV, ejection fraction<50%) that were randomly allocated, 72 completed the study (exercise training group, n=33, 63 ± 9 years, 88% men, and control group, n=39, 56 ± 11 years, 82% men). All patients underwent cardiopulmonary stress test, non-invasive high-fidelity tonometry of the radial artery, pulse wave velocity measurement using a SphygmoCor device and echocardiography before and after the completion of the training program.
Both groups reported similar medical characteristics and physical activity status. General mixed effects models revealed that the intervention group reduced pulse wave velocity by 9% (p=0.05); Emv/Vp by 14% (p=0.06); E to A ratio by 24% (p=0.004), E to Emv ratio by 8% (p=0.05), MLHFQ score by 66% (p=0.003) and the depression score by 19% (p=0.5); increased augmentation index by 29%; VTI by 4% (p=0.05), 6-minute-walk distance up to 13% (p=0.05), peak oxygen uptake by 28% (p=0.001) and peak power by 25% (p=0.005). There were no significant changes in the control group.
Interval high-intensity aerobic training, combined with strength exercise, seems to benefit aortic dilatation capacity and augmented systolic pressure in parallel with improvement in left ventricular diastolic function and quality of life.
本研究的目的是评估高强度间歇运动（即最大负荷的100%持续30秒，随后休息30秒，每周3天，每次45分钟，共锻炼12周）对慢性心力衰竭（CHF）患者左心室功能和主动脉弹性特性的影响。
本研究为III期临床试验。在100例连续入选的CHF患者（纽约心脏协会II-IV级，射血分数<50%）中，随机分配，72例完成研究（运动训练组，n = 33，63±9岁，男性占88%；对照组，n = 39，56±11岁，男性占82%）。所有患者在训练计划完成前后均接受了心肺应激试验、桡动脉无创高保真眼压测量、使用SphygmoCor设备测量脉搏波速度以及超声心动图检查。
两组患者的医学特征和身体活动状况相似。一般混合效应模型显示，干预组的脉搏波速度降低了9%（p = 0.05）；Emv/Vp降低了14%（p = 0.06）；E/A比值降低了24%（p = 0.004），E/Emv比值降低了8%（p = 0.05），MLHFQ评分降低了66%（p = 0.003），抑郁评分降低了19%（p = 0.5）；增强指数增加了29%；VTI增加了4%（p = 0.05），6分钟步行距离增加了13%（p = 0.05），峰值摄氧量增加了28%（p = 0.001），峰值功率增加了25%（p = 0.005）。对照组无显著变化。
间歇高强度有氧训练结合力量训练，似乎有利于主动脉扩张能力和收缩压增强，同时改善左心室舒张功能和生活质量。
