Laboratory of Physiological Hygiene and Exercise Science, School of Kinesiology, University of Minnesota Twin Cities , Minneapolis, MN , USA.
Free Radic Res. 2014 Jan;48(1):3-11. doi: 10.3109/10715762.2013.844341. Epub 2013 Oct 14.
Contraction-induced production of reactive oxygen species (ROS) has been implicated in oxidative stress to skeletal muscle for the past few decades. As research advances more evidence has revealed a more complete role of ROS under both physiological and pathological conditions. The current review postulated that moderate intensity of physical exercise has antioxidant and anti-inflammatory effects due to the operation and cross-talks of several redox-sensitive signal transduction pathways. The functional roles and mechanisms of action of the nuclear factor κB, mitogen-activated protein kinase, and peroxisome proliferator-activated receptor γ co-activator 1α are highlighted.
在过去的几十年里，收缩引起的活性氧（ROS）产生被认为与骨骼肌的氧化应激有关。随着研究的进展，越来越多的证据揭示了 ROS 在生理和病理条件下更为完整的作用。本综述假设，由于几种氧化还原敏感信号转导途径的运作和串扰，中等强度的体育锻炼具有抗氧化和抗炎作用。核因子κB、丝裂原激活蛋白激酶和过氧化物酶体增殖物激活受体γ共激活因子 1α 的功能作用和作用机制被强调。
