形态发生素研究：保持冷静，继续前进。
Studies of morphogens: keep calm and carry on.
机构信息
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
出版信息
Development. 2013 Oct;140(20):4119-24. doi: 10.1242/dev.095141.
Abstract
Morphogens are signaling factors that direct cell fate and tissue development at a distance from their source, and various modes of transport and interpretation have been suggested for morphogens. The recent EMBO Workshop on 'Morphogen gradients', which took place in Oxford, UK in June 2013, centered on the formation and interpretation of such morphogen gradients during development. This meeting allowed an exchange of views in light of recent results. Here, we provide a brief overview of the talks, organized in relation to several major themes of discussion at the meeting: (1) morphogen gradient formation; (2) morphogen gradient interpretation; (3) signaling networks and feedback in morphogenesis; (4) emergence of patterns; (5) scaling of patterns; (6) the control of growth; and (7) new techniques in the field.
摘要
形态发生素是远距离指导细胞命运和组织发育的信号因子，已经提出了多种形态发生素的运输和解释方式。最近在英国牛津举行的“形态发生素梯度”EMBO 研讨会集中讨论了发育过程中这种形态发生素梯度的形成和解释。此次会议根据最新的研究结果交流了观点。在这里，我们简要概述了会议的演讲，根据会议的几个主要讨论主题进行了组织：（1）形态发生素梯度的形成；（2）形态发生素梯度的解释；（3）形态发生中的信号网络和反馈；（4）模式的出现；（5）模式的扩展；（6）生长的控制；（7）该领域的新技术。
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