Rajput Saumya, Parashar Rachna, Sharma Jai Prakash, Raghuwanshi Pragati, Pakhare Abhijit P, Joshi Rajnish, Hulke Sandip
Department of Internal Medicine, All India Institute of Medical Sciences, Bhopal, Bhopal, IND.
Department of Physiology, All India Institute of Medical Sciences, Bhopal, Bhopal, IND.
Cureus. 2023 Feb 16;15(2):e35081. doi: 10.7759/cureus.35081. eCollection 2023 Feb.
Background Diabetes mellitus causes microvascular complications in the eyes and kidneys as well as the nervous system, among other parts of the body. Lungs are a potential target organ for diabetic microvascular complications and remain the least researched among diabetic patients. The aim of this study was to explore whether there is any difference in pulmonary functions in patients with diabetes mellitus compared to those without. Methodology A comparative cross-sectional study was conducted on 50 participants each with and without type II diabetes mellitus. Pulmonary function parameters, including forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1 as a percentage of FVC in percentage (FEV1%), peak expiratory flow rate in L/second (PEFR), forced expiratory flow rate in L/second in 25% of FVC (FEF25%), forced expiratory flow rate in L/second in 50% of FVC (FEF50%), forced expiratory flow rate in L/second in 75% of FVC (FEF75%), forced expiratory flow rate during 25-75% of expiration (FEF25-75%), and maximal voluntary ventilation (MVV), of both groups were analyzed using the NDD Large True Flow (Easy One) spirometer (NDD Meditechnik AG., Switzerland). A fully automated chemistry analyzer and linear chromatography were used for glycemic control measurements. Results All pulmonary function test parameter values were lower in participants with diabetes mellitus compared to those without, except FEV1% and PEFR, which indicates a mixed pattern of lung dysfunction. FVC had a significant negative correlation with the duration of diabetes (r = -0.299, p = 0.034). Conclusions Type II diabetes mellitus patients had significant dysfunction in pulmonary functions with early involvement of restrictive parameters which can be monitored/diagnosed by regularly following up patients by measuring pulmonary functions, and, hence, can be taken care of.
背景 糖尿病会导致眼睛、肾脏以及身体其他部位（包括神经系统）出现微血管并发症。肺部是糖尿病微血管并发症的潜在靶器官，在糖尿病患者中仍是研究最少的部位。本研究的目的是探讨糖尿病患者与非糖尿病患者的肺功能是否存在差异。方法 对50名患有和未患有II型糖尿病的参与者进行了一项比较性横断面研究。使用NDD大型真流量（易安）肺量计（瑞士NDD Meditechnik AG公司）分析两组的肺功能参数，包括用力肺活量（FVC）、一秒用力呼气容积（FEV1）、FEV1占FVC的百分比（FEV1%）、以升/秒为单位的呼气峰值流速（PEFR）、FVC的25%时以升/秒为单位的用力呼气流速（FEF25%）、FVC的50%时以升/秒为单位的用力呼气流速（FEF50%）、FVC的75%时以升/秒为单位的用力呼气流速（FEF75%）、呼气25%-75%期间的用力呼气流速（FEF25-75%）以及最大自主通气量（MVV）。使用全自动化学分析仪和线性色谱法进行血糖控制测量。结果 与未患糖尿病的参与者相比，患糖尿病的参与者所有肺功能测试参数值均较低，但FEV1%和PEFR除外，这表明存在混合性肺功能障碍模式。FVC与糖尿病病程呈显著负相关（r = -0.299，p = 0.034）。结论 II型糖尿病患者存在显著的肺功能障碍，限制性参数早期受累，通过定期测量肺功能对患者进行随访可对其进行监测/诊断，从而加以护理。
