Department of Biosciences, Integral University, Lucknow-226026, Uttar Pradesh, India.
Herbal Nanobiotechnology Lab, Pharmacology Division, CSIR-National Botanical Research Institute, Lucknow-226001, Uttar Pradesh, India.
Biomolecules. 2019 Feb 18;9(2):68. doi: 10.3390/biom9020068.
Chrysophanol is a unique anthraquinone having broad-spectrum therapeutic potential along with ecological importance. It is the first polyketide that has been reported to be biosynthesized in an organism-specific manner. The traditional Chinese and Korean medicinal systems provide evidence of the beneficial effects of chrysophanol on human health. The global distribution of chrysophanol encountered in two domains of life (bacteria and eukaryota) has motivated researchers to critically evaluate the properties of this compound. A plethora of literature is available on the pharmacological properties of chrysophanol, which include anticancer, hepatoprotective, neuroprotective, anti-inflammatory, antiulcer, and antimicrobial activities. However, the pharmacokinetics and toxicity studies on chrysophanol demand further investigations for it to be used as a drug. This is the first comprehensive review on the natural sources, biosynthetic pathways, and pharmacology of chrysophanol. Here we reviewed recent advancements made on the pharmacokinetics of the chrysophanol. Additionally, we have highlighted the knowledge gaps of its mechanism of action against diseases and toxicity aspects.
大黄酚是一种独特的蒽醌类化合物，具有广泛的治疗潜力和生态重要性。它是第一个被报道以生物体特异性方式生物合成的聚酮化合物。传统的中医和韩医系统提供了大黄酚对人类健康有益的证据。在细菌和真核生物两个生命领域中发现的大黄酚的全球分布，促使研究人员对该化合物的性质进行了批判性评估。关于大黄酚的药理学特性有大量文献，包括抗癌、保肝、神经保护、抗炎、抗溃疡和抗菌活性。然而，大黄酚的药代动力学和毒性研究需要进一步的研究，才能将其用作药物。这是关于大黄酚的天然来源、生物合成途径和药理学的第一篇综合评论。在这里，我们回顾了大黄酚药代动力学的最新进展。此外，我们还强调了其针对疾病的作用机制和毒性方面的知识空白。
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