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产前暴露于 900MHz 电磁场对 21 天大的大鼠睾丸的影响。

The effect of prenatal exposure to 900-MHz electromagnetic field on the 21-old-day rat testicle.

机构信息

Department of Histology and Embryology, School of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey.

出版信息

Reprod Toxicol. 2013 Dec;42:203-9. doi: 10.1016/j.reprotox.2013.09.006. Epub 2013 Oct 1.

Abstract

The aim of this study was to investigate the effect of exposure to a 900-MHz electromagnetic field (EMF) in the prenatal term on the 21-old-day rat testicle. Pregnant rats were divided into control (CG) and EMF (EMFG) groups. EMFG was exposed to 900-MHz EMF during days 13-21 of pregnancy. Newborn CG rats were obtained from the CG and newborn EMFG (NEMFG) rats from the EMFG. Testicles were extracted at postnatal day 21. Lipid peroxidation and DNA oxidation levels, apoptotic index and histopathological damage scores were compared. NEMFG rats exhibited irregularities in seminiferous tubule basal membrane and epithelium, immature germ cells in the lumen, and a decreased diameter in seminiferous tubules and thickness of epithelium. Apoptotic index, lipid peroxidation and DNA oxidation were higher in NEMFG rats than in NCG. 21-day-old rat testicles exposed to 900-MHz EMF in the prenatal term may be adversely affected, and this effect persists after birth.

摘要

本研究旨在探讨产前暴露于 900MHz 电磁场(EMF)对 21 日龄大鼠睾丸的影响。将怀孕大鼠分为对照组(CG)和 EMF 组(EMFG)。EMFG 在妊娠第 13-21 天接受 900MHz EMF 照射。CG 组新生大鼠(CG 组)和 EMFG 组新生大鼠(NEMFG 组)来自 EMFG。在生后第 21 天提取睾丸。比较脂质过氧化和 DNA 氧化水平、凋亡指数和组织病理学损伤评分。NEMFG 大鼠的曲细精管基膜和上皮不规则,管腔中有未成熟的生殖细胞,曲细精管直径和上皮厚度减小。NEMFG 大鼠的凋亡指数、脂质过氧化和 DNA 氧化均高于 NCG。产前暴露于 900MHz EMF 的 21 日龄大鼠睾丸可能受到不利影响,这种影响在出生后仍然存在。

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