Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
J Sex Med. 2013 Dec;10(12):3135-43. doi: 10.1111/jsm.12295. Epub 2013 Sep 30.
In this prospective study of localized prostate cancer patients and their partners, we analyzed how partner issues evolve over time, focusing on satisfaction with care, influence of cancer treatment, and its impact on relationship with patient, cancer worry, and personal activities.
Our study aims were twofold: (i) to determine whether the impact of treatment on patients and partners moderate over time and (ii) if receiving surgery (i.e., radical prostatectomy) influences partner issues more than other treatments.
Patients newly diagnosed with localized prostate cancer and their female partners were recruited from three states to complete surveys by mail at three time points over 12 months.
The four primary outcomes assessed in the partner analysis included satisfaction with treatment, cancer worry, and the influence of cancer and its treatment on their relationship (both general relationship and sexual relationship).
This analysis included 88 patient-partner pairs. At 6 months, partners reported that cancer had a negative impact on their sexual relationship (39%--somewhat negative and 12%--very negative). At 12 months, this proportion increased substantially (42%--somewhat negative and 29%--very negative). Partners were significantly more likely to report that their sexual relationship was worse when the patient reported having surgery (P = 0.0045, odds ratio = 9.8025, 95% confidence interval 2.076-46.296). A minority of partners reported significant negative impacts in other areas involving their personal activities (16% at 6 months and 25% at 12 months) or work life (6% at 6 months, which increased to 12% at 12 months).
From partners' perspectives, prostate cancer therapy has negative impact on sexual relationships and appears to worsen over time.
在这项针对局限性前列腺癌患者及其伴侣的前瞻性研究中，我们分析了伴侣问题随时间的变化，重点关注对治疗的满意度、癌症治疗的影响，以及其对与患者关系、癌症担忧和个人活动的影响。
我们的研究目的有两个：（i）确定治疗对患者和伴侣的影响是否随时间而缓和；（ii）如果手术（即根治性前列腺切除术）对伴侣问题的影响是否大于其他治疗。
从三个州招募新诊断为局限性前列腺癌的患者及其女性伴侣，通过邮件在 12 个月内完成三次调查。
伴侣分析中评估的四个主要结局包括对治疗的满意度、癌症担忧，以及癌症及其治疗对他们关系（一般关系和性关系）的影响。
该分析纳入了 88 对患者-伴侣。在 6 个月时，伴侣报告癌症对他们的性关系产生了负面影响（39%——有些负面，12%——非常负面）。在 12 个月时，这一比例大幅增加（42%——有些负面，29%——非常负面）。当患者报告接受手术时，伴侣更有可能报告他们的性关系更差（P=0.0045，优势比=9.8025，95%置信区间 2.076-46.296）。少数伴侣报告在其他涉及个人活动（6 个月时为 16%，12 个月时为 25%）或工作生活（6 个月时为 6%，12 个月时增加到 12%）方面存在显著的负面影响。
从伴侣的角度来看，前列腺癌治疗对性关系有负面影响，且似乎随时间恶化。
