The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
J Alzheimers Dis. 2014;39(1):71-8. doi: 10.3233/JAD-131526.
Alzheimer's disease (AD) has been shown to be associated with shrinkage of the corpus callosum mid-sagittal cross-sectional area (CCA).
To study temporal rates of corpus callosum atrophy not previously reported for early AD.
We used longitudinal MRI scans to study the rates of change of CCA and circularity (CIR), a measure of its shape, in normal controls (NC, n = 75), patients with very mild AD (AD-VM, n = 51), and mild AD (AD-M, n = 21).
There were significant reduction rates in CCA and CIR in all three groups. While CCA reduction rates were not statistically different between groups, the CIR declined faster in AD-VM (p < 0.03) and AD-M (p < 0.0001) relative to NC, and in AD-M relative to AD-VM (p < 0.0004).
CIR declines at an accelerated rate with AD severity. Its rate of change is more closely associated with AD progression than CCA or any of its sub-regions. CIR may be a useful group biomarker for objective assessment of treatments that aim to slow AD progression.
阿尔茨海默病（AD）与胼胝体中部矢状横截面积（CCA）缩小有关。
研究以前未报告的早期 AD 的胼胝体萎缩的时间率。
我们使用纵向 MRI 扫描来研究正常对照组（NC，n=75）、轻度 AD 患者（AD-M，n=21）和非常轻度 AD 患者（AD-VM，n=51）的 CCA 和圆形度（CIR）变化率，这是其形状的一种度量。
三组的 CCA 和 CIR 均有明显的减少率。虽然各组之间 CCA 的减少率没有统计学差异，但 AD-VM（p<0.03）和 AD-M（p<0.0001）相对于 NC，以及 AD-M 相对于 AD-VM（p<0.0004）的 CIR 下降更快。
随着 AD 严重程度的增加，CIR 下降速度加快。与 CCA 或其任何子区域相比，其变化率与 AD 进展的相关性更强。CIR 可能是一种有用的组生物标志物，可用于客观评估旨在减缓 AD 进展的治疗方法。
