Yau Rebecca K, Strotmeyer Elsa S, Resnick Helaine E, Sellmeyer Deborah E, Feingold Kenneth R, Cauley Jane A, Vittinghoff Eric, De Rekeneire Nathalie, Harris Tamara B, Nevitt Michael C, Cummings Steven R, Shorr Ronald I, Schwartz Ann V
Corresponding author: Rebecca K. Yau,
Diabetes Care. 2013 Dec;36(12):3985-91. doi: 10.2337/dc13-0429. Epub 2013 Oct 15.
To determine whether older adults with diabetes are at increased risk of an injurious fall requiring hospitalization.
The longitudinal Health, Aging, and Body Composition Study included 3,075 adults aged 70-79 years at baseline. Hospitalizations that included ICD-9-Clinical Modification codes for a fall and an injury were identified. The effect of diabetes with and without insulin use on the rate of first fall-related injury hospitalization was assessed using proportional hazards models.
At baseline, 719 participants had diabetes, and 117 of them were using insulin. Of the 293 participants who were hospitalized for a fall-related injury, 71 had diabetes, and 16 were using insulin. Diabetes was associated with a higher rate of injurious fall requiring hospitalization (hazard ratio [HR] 1.48 [95% CI 1.12-1.95]) in models adjusted for age, race, sex, BMI, and education. In those participants using insulin, compared with participants without diabetes, the HR was 3.00 (1.78-5.07). Additional adjustment for potential intermediaries, such as fainting in the past year, standing balance score, cystatin C level, and number of prescription medications, accounted for some of the increased risk associated with diabetes (1.41 [1.05-1.88]) and insulin-treated diabetes (2.24 [1.24-4.03]). Among participants with diabetes, a history of falling, poor standing balance score, and A1C level ≥8% were risk factors for an injurious fall requiring hospitalization.
Older adults with diabetes, in particular those using insulin, are at greater risk of an injurious fall requiring hospitalization than those without diabetes. Among those with diabetes, poor glycemic control may increase the risk of an injurious fall.
确定患有糖尿病的老年人因跌倒受伤而需住院治疗的风险是否增加。
纵向开展的健康、衰老与身体成分研究纳入了3075名基线年龄为70 - 79岁的成年人。识别出包含国际疾病分类第九版临床修订本中跌倒及损伤编码的住院病例。使用比例风险模型评估糖尿病患者使用胰岛素与否对首次因跌倒相关损伤住院率的影响。
在基线时,719名参与者患有糖尿病,其中117人正在使用胰岛素。在因跌倒相关损伤而住院的293名参与者中,71人患有糖尿病,16人正在使用胰岛素。在对年龄、种族、性别、体重指数和教育程度进行调整的模型中,糖尿病与因跌倒受伤而需住院治疗的较高发生率相关(风险比[HR]为1.48[95%可信区间为1.12 - 1.95])。在那些使用胰岛素的参与者中,与未患糖尿病的参与者相比,HR为3.00(1.78 - 5.07)。对诸如过去一年中昏厥、站立平衡评分、胱抑素C水平和处方药数量等潜在中介因素进行额外调整后,可解释与糖尿病相关的部分增加风险(1.41[1.05 - 1.88])以及胰岛素治疗的糖尿病相关风险(2.24[1.24 - 4.03])。在患有糖尿病的参与者中,跌倒史、站立平衡评分差和糖化血红蛋白水平≥8%是因跌倒受伤而需住院治疗的危险因素。
患有糖尿病的老年人,尤其是使用胰岛素的老年人,比未患糖尿病的老年人因跌倒受伤而需住院治疗的风险更高。在患有糖尿病的人群中,血糖控制不佳可能会增加因跌倒受伤的风险。