Department of Basic Public Health, Center for Disease Control and Prevention of Guangzhou, Guangzhou, 510440, China.
Institute of Public Health, Guangzhou Medical University & Guangzhou Center for Disease Control and Prevention, Guangzhou, 510440, China.
BMC Geriatr. 2024 Aug 29;24(1):717. doi: 10.1186/s12877-024-05314-5.
Several studies have demonstrated that older adults with type 2 diabetes mellitus (T2DM) have a higher risk of falls compared to those without T2DM, which may lead to disability and a lower quality of life. While, limited prospective studies have quantified the associations in southern China. We conducted a longitudinal cohort study to quantify the associations between T2DM and falls and investigate the risk factors of falls among community-dwelling elderly people in Guangzhou, China.
The population-based study included 8800 residents aged 65 and over in 11 counties of Guangzhou at baseline in 2020 and then prospectively followed up through 2022. Of 6169 participants had complete follow-up and were included in the present study. A fall event was identified by self-reported. The Cox regression was applied to quantify the associations between T2DM and falls, and hazard ratios (HRs) were calculated to the factors associated with falls among participants.
The median follow-up time for participants was 2.42 years. During the follow-up period, the incidence of falls among all participants was 21.96%. After adjusting for covariates in Cox regression models, T2DM remained a significant risk factor for falls, with HR of 1.781 (95% CI: 1.600-1.983) in the unadjusted covariates model and 1.757 (1.577-1.957) in the adjusted covariates model. Female (1.286, 1.136-1.457), older age (≥ 80: 1.448, 1.214-1.729), single marital status (1.239, 1.039-1.477), lower education level (primary school and below: 1.619, 1.004-1.361), hypertension (1.149, 1.026-1.286) and stroke (1.619, 1.176-2.228) were associated with a higher risk of falls, whereas everyday physical exercise (0.793, 0.686-0.918) was associated with a lower risk of falls.
Falls are common, with risks between T2DM and falls quantified and several factors investigated in the longitudinal cohort study among community-dwelling elderly people in Guangzhou, China. Targeted action on the risk factors may reduce the burden of falls in elderly people with T2DM in the future.
多项研究表明，2 型糖尿病（T2DM）老年患者与无 T2DM 患者相比，发生跌倒的风险更高，这可能导致残疾和生活质量下降。然而，在中国南方，有限的前瞻性研究已经量化了这些关联。我们进行了一项纵向队列研究，以量化 T2DM 与跌倒之间的关联，并调查中国广州社区居住老年人跌倒的危险因素。
这项基于人群的研究纳入了 2020 年基线时广州 11 个县的 8800 名 65 岁及以上的居民，并在 2022 年进行了前瞻性随访。6169 名完成随访的参与者被纳入本研究。通过自我报告确定跌倒事件。应用 Cox 回归来量化 T2DM 与跌倒之间的关联，并计算参与者中与跌倒相关的因素的风险比（HRs）。
参与者的中位随访时间为 2.42 年。在随访期间，所有参与者的跌倒发生率为 21.96%。在 Cox 回归模型中调整了协变量后，T2DM 仍然是跌倒的显著危险因素，未调整协变量模型中的 HR 为 1.781（95%CI：1.600-1.983），调整协变量模型中的 HR 为 1.757（1.577-1.957）。女性（1.286，1.136-1.457）、年龄较大（≥80 岁：1.448，1.214-1.729）、单身婚姻状况（1.239，1.039-1.477）、较低的教育水平（小学及以下：1.619，1.004-1.361）、高血压（1.149，1.026-1.286）和中风（1.619，1.176-2.228）与跌倒风险增加相关，而日常体育锻炼（0.793，0.686-0.918）与跌倒风险降低相关。
在中国广州的社区居住老年人中，这项纵向队列研究量化了 T2DM 与跌倒之间的关联，并调查了一些危险因素。针对这些危险因素采取行动可能会降低未来 T2DM 老年患者跌倒的负担。
