Department of Medicine, Center for Emerging Pathogens, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, USA.
Department of Medicine, Center for Immunity and Inflammation, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, USA.
Nat Immunol. 2013 Nov;14(11):1118-1126. doi: 10.1038/ni.2736.
Helminth infections are ubiquitous worldwide and can trigger potent immune responses that differ from and potentially antagonize host protective responses to microbial pathogens. In this Review we focus on the three main killers in infectious disease-AIDS, tuberculosis and malaria-and critically assesses whether helminths adversely influence host control of these diseases. We also discuss emerging concepts for how M2 macrophages and helminth-modulated dendritic cells can potentially influence the protective immune response to concurrent infections. Finally, we present evidence advocating for more efforts to determine how and to what extent helminths interfere with the successful control of specific concurrent coinfections.
寄生虫感染在全球范围内普遍存在,可引发强烈的免疫反应,这些反应与宿主对微生物病原体的保护性反应不同,甚至可能拮抗。在这篇综述中,我们重点关注传染病的三大主要杀手——艾滋病、结核病和疟疾,并批判性地评估了寄生虫是否会对宿主控制这些疾病产生不利影响。我们还讨论了 M2 巨噬细胞和寄生虫调节的树突状细胞如何潜在地影响对并发感染的保护性免疫反应的新兴概念。最后,我们提出了证据,主张需要更多的努力来确定寄生虫是如何以及在何种程度上干扰对特定并发混合感染的成功控制。