Biomed Res Int. 2013;2013:215989. doi: 10.1155/2013/215989. Epub 2013 Sep 16.
This work suggests a fast estimation method of the lateral ventricles volume from a 2D image and then determines if this volume is correlated with the cerebrospinal fluid flow at the aqueductal and cerebral levels in neurodegenerative diseases.
Forty-five elderly patients suffering from Alzheimer's disease (19), normal pressure hydrocephalus (13), and vascular dementia (13) were involved and underwent anatomical and phase contrast MRI scans. Lateral ventricles and stroke volumes were assessed on anatomical and phase contrast scans, respectively. A common reference plane was used to calculate the lateral ventricles' area on 2D images.
The largest volumes were observed in hydrocephalus patients. The linear regression between volumes and areas was computed, and a strong positive correlation was detected (R² = 0.9). A derived equation was determined to represent the volumes for any given area. On the other hand, no significant correlations were detected between ventricles and stroke volumes (R² ≤ 0.15).
Lateral ventricles volumes are significantly proportional to the 2D reference section area and could be used for patients' follow-up even if 3D images are unavailable. The cerebrospinal fluid fluctuations in brain disorders may depend on many physiological parameters other than the ventricular morphology.
本研究提出了一种从二维图像快速估计侧脑室体积的方法，然后确定该体积是否与神经退行性疾病中导水管和脑水平的脑脊液流动相关。
共纳入 45 例老年患者，其中阿尔茨海默病（19 例）、正常压力脑积水（13 例）和血管性痴呆（13 例），并进行解剖和相位对比 MRI 扫描。分别在解剖和相位对比扫描上评估侧脑室和脑卒中容积。使用共同的参考平面计算二维图像上的侧脑室面积。
脑积水患者的侧脑室体积最大。计算了体积与面积之间的线性回归，发现存在很强的正相关（R²=0.9）。确定了一个衍生方程来代表任何给定面积的体积。另一方面，侧脑室与脑卒中容积之间未检测到显著相关性（R²≤0.15）。
侧脑室体积与二维参考截面面积显著相关，即使没有 3D 图像，也可用于患者的随访。脑疾病中的脑脊液波动可能取决于除脑室形态以外的许多生理参数。
