红藻溴酚类化合物作为葡萄糖-6-磷酸脱氢酶抑制剂。

Red algal bromophenols as glucose 6-phosphate dehydrogenase inhibitors.

机构信息

Faculty and Graduate School of Fisheries Sciences, Hokkaido University, Minato, Hakodate, Hokkaido 041-8611, Japan.

出版信息

Mar Drugs. 2013 Oct 22;11(10):4050-7. doi: 10.3390/md11104050.

DOI:10.3390/md11104050

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3826149/

Abstract

Five bromophenols isolated from three Rhodomelaceae algae (Laurencia nipponica, Polysiphonia morrowii, Odonthalia corymbifera) showed inhibitory effects against glucose 6-phosphate dehydrogenase (G6PD). Among them, the symmetric bromophenol dimer (5) showed the highest inhibitory activity against G6PD.

摘要

五种从三种红藻（日本红叶藻、密枝马尾藻、丛生指管藻）中分离得到的溴酚类化合物对葡萄糖-6-磷酸脱氢酶（G6PD）表现出抑制作用。其中，对称溴酚二聚体（5）对 G6PD 的抑制活性最高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd9f/3826149/3de4b6c810b4/marinedrugs-11-04050-g001.jpg

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