用于相干拉曼散射显微镜的消色差微型透镜系统。
Achromatic miniature lens system for coherent Raman scattering microscopy.
作者信息
Mittal Richa, Balu Mihaela, Wilder-Smith Petra, Potma Eric O
机构信息
Beckman Laser Institute, University of California, Irvine, CA 92697, USA.
出版信息
Biomed Opt Express. 2013 Sep 19;4(10):2196-206. doi: 10.1364/BOE.4.002196. eCollection 2013.
We discuss the design and performance of a miniature objective lens optimized for coherent Raman scattering microscopy. The packaged lens assembly has a numerical aperture of 0.51 in water and an outer diameter of 8 mm. The lens system exhibits minimum chromatic aberrations, and produces coherent Raman scattering images with sub-micrometer lateral resolution (0.648 μm) using near-infrared excitation pulses. We demonstrate that despite the small dimensions of the miniature objective, the performance of this lens system is comparable to standard microscope objective lenses, offering opportunities for miniaturizing coherent Raman scattering imaging probes without sacrificing the image quality.
我们讨论了一种为相干拉曼散射显微镜优化的微型物镜的设计与性能。封装后的透镜组件在水中的数值孔径为0.51，外径为8毫米。该透镜系统具有最小色差，并使用近红外激发脉冲产生具有亚微米横向分辨率（0.648μm）的相干拉曼散射图像。我们证明，尽管微型物镜尺寸小，但该透镜系统的性能与标准显微镜物镜相当，为在不牺牲图像质量的情况下使相干拉曼散射成像探头小型化提供了机会。
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