微小RNA（miRNA）成熟的途径。

The pathway of miRNA maturation.

作者信息

Sand Michael

机构信息

Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, Bochum, Germany.

出版信息

Methods Mol Biol. 2014;1095:3-10. doi: 10.1007/978-1-62703-703-7_1.

DOI:10.1007/978-1-62703-703-7_1

PMID:24166299

Abstract

MicroRNAs (miRNAs) are a novel class of 17-23 nucleotide short, nonprotein-coding RNA molecules which have emerged to be key players in posttranscriptional gene regulation. In this chapter we give an in-depth review of the classic, canonical mammalian miRNA maturation pathway and discuss new, noncanonical alternatives such as the mirtron pathway which were recently described.

摘要

微小RNA（miRNA）是一类新型的由17 - 23个核苷酸组成的短链非蛋白质编码RNA分子，已成为转录后基因调控的关键因子。在本章中，我们将深入综述经典的、规范的哺乳动物miRNA成熟途径，并讨论诸如最近描述的镜像RNA途径等新的非规范替代途径。