Kemp A S, Cripps A W, Brown S
Clin Exp Immunol. 1980 May;40(2):388-95.
The effects of IgA and IgG isolated from normal human serum on neutrophil and monocyte migration were examined. IgA inhibited neutrophil chemotaxis towards casein and neutrophil random migration in serum-containing medium. The dose-response curve for the inhibition of the two forms of stimulated cell movement was similar suggesting that inhibition of both forms of movement may occur by a common mechanism. It was concluded that the inhibition was mediated by polymeric and aggregated forms of IgA but not by IgA present in normal serum. IgA at concentrations which inhibited stimulated cell movement did not inhibit the phagocytosis of zymosan particles by neutrophils. In contrast to IgA, aggregated IgG did not inhibit neutrophil chemotaxis at concentrations which were markedly inhibitory to random migration in serum-containing medium, indicating a differential effect of IgA and IgG aggregates on cell migration.
研究了从正常人血清中分离出的IgA和IgG对中性粒细胞和单核细胞迁移的影响。IgA抑制中性粒细胞向酪蛋白的趋化作用以及在含血清培养基中的中性粒细胞随机迁移。抑制这两种形式的刺激细胞运动的剂量反应曲线相似，表明两种运动形式的抑制可能通过共同机制发生。得出的结论是，这种抑制是由IgA的聚合体和聚集形式介导的，而不是由正常血清中的IgA介导的。抑制刺激细胞运动的浓度的IgA并不抑制中性粒细胞对酵母聚糖颗粒的吞噬作用。与IgA相反，聚集的IgG在对含血清培养基中的随机迁移有明显抑制作用的浓度下并不抑制中性粒细胞趋化作用，表明IgA和IgG聚集物对细胞迁移有不同的影响。
