Wang Tian-Xiao, Yin Zhen-Hua, Zhang Wei, Peng Tao, Kang Wen-Yi
Institute of Chinese Materia Medica, Henan University, Kaifeng 475004, China.
Zhongguo Zhong Yao Za Zhi. 2013 Jul;38(14):2328-33.
Twelve compounds were isolated from Psoralea corylifolia and their structures were identified as isopsoralen (1), psoralen (2), 8-methoxypsoralen (3), psoralidin (4), corylin (5), bavachin (6), daidzein (7), corylifolinin (8), bavachinin (9), neobavaisoflavone (10), daidzin (11) and astragalin (12). The results showed that psoralidin had the activity of scavenging DPPH free radicals activity (IC50 43.85 mg x L(-1)). Psoralidin (IC50 1.32 mg x L(-1))c, oryfolin (IC50 4.97 mg x L(-1)), daidzin (IC50 10.47 mg x S(-1)), daidzein (IC50 34.22 mg) x L(-1)) and astragalin (IC50 31.27 mg x L(-1)) had the activity of scavenging ABTS free radical. Psoralidin (IC50 40.74 mg x L(-1)), coryfolin (IC50 45.73 mg x L(-1)) and daidzein (IC50 49.44 mg x L(-1)) had alpha-glucosidase inhibitory activity. Corylifolinin and neobavaisoflavone had significantly effect of inhibiting SA, MRSA and ESBLs-SA (MIC 0. 781 3, 1.562, 5, 0.781 25 microg x disc(-1) and 6.25, 6.25, 6.25 microg x disc(-1).
从补骨脂中分离出12种化合物，其结构被鉴定为异补骨脂素（1）、补骨脂素（2）、8-甲氧基补骨脂素（3）、补骨脂定（4）、补骨脂宁（5）、紫花前胡苷（6）、大豆苷元（7）、补骨脂苷（8）、紫花前胡素（9）、新补骨脂异黄酮（10）、大豆苷（11）和紫云英苷（12）。结果表明，补骨脂定具有清除DPPH自由基的活性（IC50为43.85 mg·L⁻¹）。补骨脂定（IC50为1.32 mg·L⁻¹）、补骨脂宁（IC50为4.97 mg·L⁻¹）、大豆苷（IC50为10.47 mg·S⁻¹）、大豆苷元（IC50为34.22 mg·L⁻¹）和紫云英苷（IC50为31.27 mg·L⁻¹）具有清除ABTS自由基的活性。补骨脂定（IC50为40.74 mg·L⁻¹）、补骨脂宁（IC50为45.73 mg·L⁻¹）和大豆苷元（IC50为49.44 mg·L⁻¹）具有α-葡萄糖苷酶抑制活性。补骨脂苷和新补骨脂异黄酮对金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和产超广谱β-内酰胺酶金黄色葡萄球菌有显著抑制作用（MIC分别为0.781 3、1.562、5、0.781 25 μg·片⁻¹和6.25、6.25、6.25 μg·片⁻¹）。
