通过 S-亚硝基硫醇将亚硝酸盐转化为一氧化氮。
Conversion of nitrite to nitric oxide at zinc via S-nitrosothiols.
机构信息
Department of Chemistry, Georgetown University, Box 571227-1227, Washington, D.C. 20057, USA.
出版信息
Chem Commun (Camb). 2014 Jan 7;50(2):168-70. doi: 10.1039/c3cc46102e.
PMID:24217415
Abstract
Nitrite is an important reservoir of nitric oxide activity in the plasma and cells. Using a biomimetic model, we demonstrate the conversion of zinc-bound nitrite in the tris(pyrazolyl)borate complex (iPr2)TpZn(NO2) to the corresponding S-nitrosothiol RSNO and zinc thiolate (iPr2)TpZn-SR via reaction with thiols H-SR. Decomposition of the S-nitrosothiol formed releases nitric oxide gas.
摘要
亚硝酸盐是血浆和细胞中一氧化氮活性的重要储存库。我们使用仿生模型证明了三（吡唑基）硼酸盐配合物（iPr2）TpZn（NO2）中与锌结合的亚硝酸盐与硫醇 H-SR 反应转化为相应的 S-亚硝酰硫醇 RSNO 和锌硫醇（iPr2）TpZn-SR。形成的 S-亚硝酰硫醇分解释放出一氧化氮气体。
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