Thier P, Axmann D, Giedke H
Electroencephalogr Clin Neurophysiol. 1986 Jun;63(6):570-81. doi: 10.1016/0013-4694(86)90144-6.
Event-related cortical potentials were recorded in 11 patients with primary depression and 11 healthy control subjects during a serial choice reaction task. Each new trial was voluntarily initiated when the subject pressed a microswitch; an acoustic go or no-go signal followed after a fixed interval. This elicited a Bereitschaftspotential (BP), a contingent negative variation (CNV), acoustically evoked potentials (N1, P2, P3), and a post-imperative negative variation (PINV) in direct succession. These were evaluated conventionally and by principal component analysis (PCA). Patients exhibited significantly longer reaction times and more negative PINVs. BP and CNV did not differ between groups. In conventional amplitude measurement small P3 amplitudes in depressives may be feigned by markedly negative PINVs.
在一项连续选择反应任务中，对11名原发性抑郁症患者和11名健康对照者记录了事件相关皮质电位。每次新试验在受试者按下微动开关时自动启动；在固定间隔后会出现听觉的执行或不执行信号。这依次引发了准备电位（BP）、伴随负变化（CNV）、听觉诱发电位（N1、P2、P3）以及命令后负变化（PINV）。对这些电位进行了传统评估以及主成分分析（PCA）。患者表现出明显更长的反应时间和更负的PINV。两组之间的BP和CNV没有差异。在传统幅度测量中，抑郁症患者中较小的P3幅度可能被明显负性的PINV所掩盖。
